(6-bromo-5-trideuteromethoxy-dideuteromethyl-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone

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Chemical Name:(6-bromo-5-trideuteromethoxy-dideuteromethyl-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone
CAS No.:1386986-48-6
Molecular Formula:C₁₆H₁₃BrN₂O₂
Molecular Weight:350.156
Hs Code.:

Synonyms:(6-bromo-5-trideuteromethoxy-dideuteromethyl-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone

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Chemical Property of (6-bromo-5-trideuteromethoxy-dideuteromethyl-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone

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Technology Process of (6-bromo-5-trideuteromethoxy-dideuteromethyl-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone

There total 6 articles about (6-bromo-5-trideuteromethoxy-dideuteromethyl-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 618-32-6
Benzoyl bromide

: 1386986-47-5
5-trideuteromethoxy-dideuteromethyl-1H-pyrrolo[2,3-b]pyridine 7-oxide

: 1386986-48-6
(6-bromo-5-trideuteromethoxy-dideuteromethyl-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone

Guidance literature:: With 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; at 20 ℃; for 18.5h; Inert atmosphere;

Reference yield:

: 858116-66-2
5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine

: 1386986-48-6
(6-bromo-5-trideuteromethoxy-dideuteromethyl-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane / 0.75 h / -78 °C / Inert atmosphere

1.2: 0.25 h / -78 - 0 °C / Inert atmosphere

1.3: 0 °C / Inert atmosphere

2.1: ethanol; sodium borodeuteride / 2 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

3.2: 3 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / 1,2-dimethoxyethane / 0 - 20 °C

5.2: pH 9

6.1: 1,1,1,3,3,3-hexamethyl-disilazane / dichloromethane / 18.5 h / 20 °C / Inert atmosphere

With n-butyllithium; sodium borodeuteride; ethanol; tetrabutyl ammonium fluoride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1386986-43-1
1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-deuterocarbaldehyde

: 1386986-48-6
(6-bromo-5-trideuteromethoxy-dideuteromethyl-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol; sodium borodeuteride / 2 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

2.2: 3 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / 1,2-dimethoxyethane / 0 - 20 °C

4.2: pH 9

5.1: 1,1,1,3,3,3-hexamethyl-disilazane / dichloromethane / 18.5 h / 20 °C / Inert atmosphere

With sodium borodeuteride; ethanol; tetrabutyl ammonium fluoride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; mineral oil;