3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-1-methylpyrazole-5-carboxylic acid

Base Information

Chemical Name:3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-1-methylpyrazole-5-carboxylic acid
CAS No.:161463-31-6
Molecular Formula:C₂₃H₂₃N₃O₂
Molecular Weight:373.455
Hs Code.:

Synonyms:3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-1-methylpyrazole-5-carboxylic acid

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Chemical Property of 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-1-methylpyrazole-5-carboxylic acid

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Technology Process of 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-1-methylpyrazole-5-carboxylic acid

There total 7 articles about 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-1-methylpyrazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 137860-65-2
4'-(3-Butyl-5-hydroxymethyl-1-methyl-1H-pyrazol-4-ylmethyl)-biphenyl-2-carbonitrile

: 161463-31-6
3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-1-methylpyrazole-5-carboxylic acid

Guidance literature:: With sodium dichromate; sulfuric acid; water; at 35 ℃; for 5h;
DOI:10.1248/cpb.42.1617

Reference yield:

: 591-78-6
n-hexan-2-one

: 161463-31-6
3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-1-methylpyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 56 percent / Na / toluene / 2 h / 55 °C

2: 64 percent / N,N-diisopropylethylamine, LiBr / tetrahydrofuran / 15 h / Heating

3: hydrazine hydrate / ethanol / 2 h / Heating

4: DBU / acetone / 8 h / 45 °C

5: BBr₃ / CH₂Cl₂ / 13 h / 0 - 20 °C

6: Na₂CO₃, H₂O / dioxane / 3 h / Heating

7: 32 percent / Na₂Cr₂O₇*2H₂O, H₂O, H₂SO₄ / 5 h / 35 °C

With sodium dichromate; sulfuric acid; water; sodium; boron tribromide; sodium carbonate; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium bromide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetone; toluene;
DOI:10.1248/cpb.42.1617

Reference yield:

: 124806-74-2
1-Methoxy-2,4-octandione

: 161463-31-6
3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-1-methylpyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 64 percent / N,N-diisopropylethylamine, LiBr / tetrahydrofuran / 15 h / Heating

2: hydrazine hydrate / ethanol / 2 h / Heating

3: DBU / acetone / 8 h / 45 °C

4: BBr₃ / CH₂Cl₂ / 13 h / 0 - 20 °C

5: Na₂CO₃, H₂O / dioxane / 3 h / Heating

6: 32 percent / Na₂Cr₂O₇*2H₂O, H₂O, H₂SO₄ / 5 h / 35 °C

With sodium dichromate; sulfuric acid; water; boron tribromide; sodium carbonate; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium bromide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetone;
DOI:10.1248/cpb.42.1617