(R)-4-Cyclohexyl-3-((1S,4aR,8aS)-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-oxazolidin-2-one

Base Information

Chemical Name:(R)-4-Cyclohexyl-3-((1S,4aR,8aS)-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-oxazolidin-2-one
CAS No.:94417-68-2
Molecular Formula:C₂₀H₂₉NO₃
Molecular Weight:331.455
Hs Code.:

Synonyms:(R)-4-Cyclohexyl-3-((1S,4aR,8aS)-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-oxazolidin-2-one

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Chemical Property of (R)-4-Cyclohexyl-3-((1S,4aR,8aS)-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-oxazolidin-2-one

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Technology Process of (R)-4-Cyclohexyl-3-((1S,4aR,8aS)-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-oxazolidin-2-one

There total 6 articles about (R)-4-Cyclohexyl-3-((1S,4aR,8aS)-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 94418-33-4
(4R)-3-((E,E)-2',8',10'-undecatrienoyl)-4-cyclohexyl-2-oxazolidinone

: 94481-94-4
(4R)-3-((4'R,5'R,6'S)-bicyclo<4.4.0>decene-4'-carbonyl)-4-cyclohexyl-2-oxazolidinone

: 94417-68-2
(R)-4-Cyclohexyl-3-((1S,4aR,8aS)-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-oxazolidin-2-one

Guidance literature:: With dimethylaluminum chloride; In dichloromethane; at -30 ℃; for 5h; Yields of byproduct given;
DOI:10.1016/S0040-4039(01)90184-4

Reference yield:

: 90319-52-1,7480-32-2
(4R)-phenyl-2-oxazolidinone

: 94417-68-2
(R)-4-Cyclohexyl-3-((1S,4aR,8aS)-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / hydrogen / 5percent rhodium on alumina / methanol / 15 h / 760 Torr

2: 52 percent / 1.) n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 10 min; 2.) -78 deg C then r.t.

3: dimethylaluminum chloride / CH₂Cl₂; toluene / 5 h / -30 °C

With n-butyllithium; hydrogen; dimethylaluminum chloride; Rh/Al₂O₃; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/ja00212a037

Reference yield:

: 104461-70-3
(E,E)-2,8,10-undecatrienoic acid chloride

: 94417-68-2
(R)-4-Cyclohexyl-3-((1S,4aR,8aS)-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / 1.) n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 10 min; 2.) -78 deg C then r.t.

2: dimethylaluminum chloride / CH₂Cl₂; toluene / 5 h / -30 °C

With n-butyllithium; dimethylaluminum chloride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja00212a037