1-(2-amino-3-fluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-ethyl-1, 4-dihydro-4-oxoquinoline

Base Information

Chemical Name:1-(2-amino-3-fluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-ethyl-1, 4-dihydro-4-oxoquinoline
CAS No.:1315179-73-7
Molecular Formula:C₂₃H₂₂FN₃O₂
Molecular Weight:391.445
Hs Code.:

Synonyms:1-(2-amino-3-fluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-ethyl-1, 4-dihydro-4-oxoquinoline

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Chemical Property of 1-(2-amino-3-fluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-ethyl-1, 4-dihydro-4-oxoquinoline

Chemical Property:

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Technology Process of 1-(2-amino-3-fluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-ethyl-1, 4-dihydro-4-oxoquinoline

There total 4 articles about 1-(2-amino-3-fluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-ethyl-1, 4-dihydro-4-oxoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₃F₂N₃O₂

: 1315179-73-7
1-(2-amino-3-fluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-ethyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 100 ℃; for 1h;

Reference yield:

: 625446-22-2
4-bromo-2-fluoroacetophenone

: 1315179-73-7
1-(2-amino-3-fluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-ethyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 0.67 h / Reflux

2.1: triphenylphosphine; sodium hydrogencarbonate / palladium diacetate / toluene; ethanol; water / 3.5 h / Reflux; Inert atmosphere

3.1: ethyl acetate; ethanol / 12.3 h / Reflux

3.2: 4 h / 60 °C

4.1: potassium carbonate / dimethyl sulfoxide / 1 h / 100 °C

With sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; palladium diacetate; In methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate; toluene;

Reference yield:

: 1315180-12-1
(E)-1-(4-bromo-2-fluorophenyl)-3-dimethylamino-2-penten-1-one

: 1315179-73-7
1-(2-amino-3-fluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-ethyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; sodium hydrogencarbonate / palladium diacetate / toluene; ethanol; water / 3.5 h / Reflux; Inert atmosphere

2.1: ethyl acetate; ethanol / 12.3 h / Reflux

2.2: 4 h / 60 °C

3.1: potassium carbonate / dimethyl sulfoxide / 1 h / 100 °C

With sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; palladium diacetate; In ethanol; water; dimethyl sulfoxide; ethyl acetate; toluene;