N,N-DIMETHYLANILINE-D3 (N-METHYL-D3)

Base Information

• Chemical Name: N,N-DIMETHYLANILINE-D3 (N-METHYL-D3)
• CAS No.: 88889-00-3
• Molecular Formula: C8H8 D3 N
• Molecular Weight: 124.158
• Mol file: 88889-00-3.mol

Synonyms:N,N-DIMETHYLANILINE-D3 (N-METHYL-D3)

Chemical Property of N,N-DIMETHYLANILINE-D3 (N-METHYL-D3)

Chemical Property:

• PSA: 3.24000
• LogP: 1.75260

Purity/Quality:

98 atom % D ^*data from raw suppliers

N,N-Dimethylaniline-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N,N-Dimethylaniline-d3 (N-methyl-d3) (CAS# 88889-00-3) is a useful isotopically labeled research compound.

Technology Process of N,N-DIMETHYLANILINE-D3 (N-METHYL-D3)

There total 6 articles about N,N-DIMETHYLANILINE-D3 (N-METHYL-D3) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

iodomethane-d3 (865-50-9) + N-methylaniline (100-61-8) → N-methyl-N-(methyl-d3)aniline (88889-00-3)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium hydroxide; In water; benzene; at 90 ℃; for 24h; Schlenk technique;

DOI:10.1039/c9ob01946d

Reference yield: 40.1%

N-carbomethoxy-N-methylaniline (28685-60-1) → N-methyl-N-(methyl-d3)aniline (88889-00-3)

Guidance literature:

With lithium aluminium deuteride; In tetrahydrofuran; for 3h; Heating;

DOI:10.1021/ja0511927

Reference yield:

paraformaldehyde-d2 (1664-98-8,43094-80-0) + N-methylaniline (100-61-8) → N-methyl-N-(methyl-d3)aniline (88889-00-3)

Guidance literature:

paraformaldehyde-d2; With sulfuric acid; sodium hydroxide; In water;

N-methylaniline; With sodium borodeuteride; In tetrahydrofuran; water; at 0 - 20 ℃;

DOI:10.1002/chem.200902387

upstream raw materials:

N,N-dimethyl-aniline

d6-dimethyl sulfate

N-methylaniline

iodomethane-d3

Downstream raw materials:

N-nitroso-N-(trideuteriomethyl)aniline

N-(methyl-d₃)aniline

N-methylaniline

C₂₂H₁₈⁽²⁾H₂N₂