3-(4-chlorophenyl)-8-(4-(4-fluorophenyl)butyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride

Base Information

Chemical Name:3-(4-chlorophenyl)-8-(4-(4-fluorophenyl)butyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride
CAS No.:1366348-85-7
Molecular Formula:C₂₃H₂₇ClFNO*ClH
Molecular Weight:424.386
Hs Code.:

Synonyms:3-(4-chlorophenyl)-8-(4-(4-fluorophenyl)butyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride

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Chemical Property of 3-(4-chlorophenyl)-8-(4-(4-fluorophenyl)butyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride

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Technology Process of 3-(4-chlorophenyl)-8-(4-(4-fluorophenyl)butyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride

There total 2 articles about 3-(4-chlorophenyl)-8-(4-(4-fluorophenyl)butyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.5%

: 54540-58-8
1-(4-chlorobutyl)-4-fluorobenzene

: 3-(4-chlorophenyl)-8-azabicyclo[3.2.1]octan-3-ol

: 1366348-85-7
3-(4-chlorophenyl)-8-(4-(4-fluorophenyl)butyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride

Guidance literature:: 1-(4-chlorobutyl)-4-fluorobenzene; 3-(4-chlorophenyl)-8-azabicyclo[3.2.1]octan-3-ol; With potassium carbonate; potassium iodide; In 1,2-dimethoxyethane; for 16h; Reflux; Inert atmosphere;

With hydrogenchloride;
DOI:10.1016/j.bmc.2012.01.022

Reference yield:

: 3874-54-2,41167-07-1
4-(4-fluorophenyl)-4-oxo-n-butyl chloride

: 1366348-85-7
3-(4-chlorophenyl)-8-(4-(4-fluorophenyl)butyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; mercury dichloride; zinc / toluene / 5 h / Reflux

2: potassium carbonate; potassium iodide / 1,2-dimethoxyethane / 16 h / Reflux; Inert atmosphere

With hydrogenchloride; potassium carbonate; potassium iodide; mercury dichloride; zinc; In 1,2-dimethoxyethane; toluene;
DOI:10.1016/j.bmc.2012.01.022