Technology Process of Diethyl [(2-isocyanophenyl)methyl]phosphonate
There total 4 articles about Diethyl [(2-isocyanophenyl)methyl]phosphonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 97 percent / H2 / 10 percent Pd/C / ethanol / 72 h / 100 °C / 38786.1 Torr
2: 57 percent / aq. KOH; BnEt3NCl / CH2Cl2 / Heating
With
potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; hydrogen;
10% palladium on active carbon;
In
ethanol; dichloromethane;
DOI:10.1055/s-2001-16808
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 84 percent / KF / tetrahydrofuran / 2 h / 40 °C
2: 97 percent / H2 / 10 percent Pd/C / ethanol / 72 h / 100 °C / 38786.1 Torr
3: 57 percent / aq. KOH; BnEt3NCl / CH2Cl2 / Heating
With
potassium fluoride; potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; hydrogen;
10% palladium on active carbon;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1055/s-2001-16808
- Guidance literature:
-
Multi-step reaction with 3 steps
1: toluene / 120 °C / Inert atmosphere
2: palladium on activated charcoal; hydrogen / Inert atmosphere
3: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / Inert atmosphere
With
palladium on activated charcoal; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; potassium hydroxide;
In
dichloromethane; toluene;
1: |Michaelis-Arbuzov Synthesis / 3: |Hofmann Isonitrile Synthesis;
DOI:10.1016/j.ejmech.2015.06.031
