tert-butyl 4-(5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl)benzylcarbamate

Base Information

Chemical Name:tert-butyl 4-(5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl)benzylcarbamate
CAS No.:1610521-00-0
Molecular Formula:C₂₆H₃₄N₄O₅S₂
Molecular Weight:546.712
Hs Code.:

Synonyms:tert-butyl 4-(5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl)benzylcarbamate

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Chemical Property of tert-butyl 4-(5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl)benzylcarbamate

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Technology Process of tert-butyl 4-(5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl)benzylcarbamate

There total 5 articles about tert-butyl 4-(5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 489446-42-6
4-((tert-butoxycarbonylamino)methyl)phenylboronic acid

: 1610520-84-7
(R)-7-bromo-5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)thieno[3,2-c]pyridin-4(5H)-one

: 1610521-00-0
tert-butyl 4-(5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl)benzylcarbamate

Guidance literature:: With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; In isopropyl alcohol; at 110 ℃; for 1h; Microwave irradiation;

Reference yield:

: 28948-60-9
2-bromothieno[3,2-c]pyridin-4(5H)-one

: 1610521-00-0
tert-butyl 4-(5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - -60 °C / Inert atmosphere

1.2: 1 h / -60 - 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran / 24 h / 20 °C

3.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C

3.2: 20 °C

4.1: acetic acid / methanol / 0.25 h / 20 °C

4.2: 1 h / 50 °C

5.1: potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / isopropyl alcohol / 1 h / 110 °C / Microwave irradiation

With N-Bromosuccinimide; n-butyllithium; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; caesium carbonate; acetic acid; In tetrahydrofuran; methanol; hexane; isopropyl alcohol;

Reference yield:

: 1610520-27-8
4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2-carbaldehyde

: 1610521-00-0
tert-butyl 4-(5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 24 h / 20 °C

2.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C

2.2: 20 °C

3.1: acetic acid / methanol / 0.25 h / 20 °C

3.2: 1 h / 50 °C

4.1: potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / isopropyl alcohol / 1 h / 110 °C / Microwave irradiation

With N-Bromosuccinimide; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; caesium carbonate; acetic acid; In tetrahydrofuran; methanol; isopropyl alcohol;