1H-Pyrazole-3-carboxylic acid, 4-cyano-5-(3-methyl-2-benzofuranyl)-1-phenyl-, ethyl ester

Base Information

Chemical Name:1H-Pyrazole-3-carboxylic acid, 4-cyano-5-(3-methyl-2-benzofuranyl)-1-phenyl-, ethyl ester
CAS No.:883554-84-5
Molecular Formula:C22H17 N3 O3
Molecular Weight:371.39
Hs Code.:
Mol file:883554-84-5.mol

Synonyms:1H-Pyrazole-3-carboxylic acid, 4-cyano-5-(3-methyl-2-benzofuranyl)-1-phenyl-, ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrazole-3-carboxylic acid, 4-cyano-5-(3-methyl-2-benzofuranyl)-1-phenyl-, ethyl ester

Chemical Property:

PSA：81.05000
LogP:4.64228

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-3-carboxylic acid, 4-cyano-5-(3-methyl-2-benzofuranyl)-1-phenyl-, ethyl ester

There total 2 articles about 1H-Pyrazole-3-carboxylic acid, 4-cyano-5-(3-methyl-2-benzofuranyl)-1-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 53554-69-1
3-(3-methylbenzofuran-2-yl)-3-oxopropanenitrile

: 28663-68-5
ethyl chloro(2-phenylhydrazono)acetate

: 883554-84-5
3-(ethoxycarbonyl)-5-(3-methylbenzofuran-2-yl)-1-phenylpyrazole-4-carbonitrile

Guidance literature:: 3-(3-methylbenzofuran-2-yl)-3-oxopropanenitrile; With sodium ethanolate; In ethanol; for 0.166667h;

ethyl chloro(2-phenylhydrazono)acetate; In ethanol; at 20 ℃; for 12h;

Reference yield:

: 22367-82-4
ethyl 3-methyl-1-benzofuran-2-carboxylate

: 883554-84-5
3-(ethoxycarbonyl)-5-(3-methylbenzofuran-2-yl)-1-phenylpyrazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 68 percent / sodium hydride / benzene; dimethylformamide / 4 h / Heating

2.1: sodium ethoxide / ethanol / 0.17 h

2.2: 75 percent / ethanol / 12 h / 20 °C

With sodium ethanolate; sodium hydride; In ethanol; N,N-dimethyl-formamide; benzene;