N-<2-<5-O--2-deoxy-β-D-ribofuranosyl>-3-methyl-7-oxo-2H-pyrazolo<4,3-d>pyrimidin-5-yl>-2-methylpropanamide

Base Information

Chemical Name:N-<2-<5-O--2-deoxy-β-D-ribofuranosyl>-3-methyl-7-oxo-2H-pyrazolo<4,3-d>pyrimidin-5-yl>-2-methylpropanamide
CAS No.:138856-94-7
Molecular Formula:C₃₆H₃₉N₅O₇
Molecular Weight:653.735
Hs Code.:

N-<2-<5-O-<bis(4-methoxyphenyl)phenylmethyl>-2-deoxy-β-D-ribofuranosyl>-3-methyl-7-oxo-2H-pyrazolo<4,3-d>pyrimidin-5-yl>-2-methylpropanamide

Synonyms:N-<2-<5-O--2-deoxy-β-D-ribofuranosyl>-3-methyl-7-oxo-2H-pyrazolo<4,3-d>pyrimidin-5-yl>-2-methylpropanamide

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Chemical Property of N-<2-<5-O--2-deoxy-β-D-ribofuranosyl>-3-methyl-7-oxo-2H-pyrazolo<4,3-d>pyrimidin-5-yl>-2-methylpropanamide

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Technology Process of N-<2-<5-O--2-deoxy-β-D-ribofuranosyl>-3-methyl-7-oxo-2H-pyrazolo<4,3-d>pyrimidin-5-yl>-2-methylpropanamide

There total 8 articles about N-<2-<5-O--2-deoxy-β-D-ribofuranosyl>-3-methyl-7-oxo-2H-pyrazolo<4,3-d>pyrimidin-5-yl>-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 138836-93-8
N-<2-(2-deoxy-β-D-ribofuranosyl)-3-methyl-7-oxo-1H-pyrazolo<4,3-d>pyrimidin-5-yl>-2-methylpropanamide

: 138856-94-7
N-<2-<5-O--2-deoxy-β-D-ribofuranosyl>-3-methyl-7-oxo-2H-pyrazolo<4,3-d>pyrimidin-5-yl>-2-methylpropanamide

Guidance literature:: With pyridine; at 4 ℃;
DOI:10.1021/ja00030a050

Reference yield:

: 28668-07-7
ethyl 3-methyl-4-nitro-1H-pyrazole-5-carboxylate

: 138856-94-7
N-<2-<5-O--2-deoxy-β-D-ribofuranosyl>-3-methyl-7-oxo-2H-pyrazolo<4,3-d>pyrimidin-5-yl>-2-methylpropanamide

Guidance literature:: Multi-step reaction with 7 steps

1: 44 percent / NaH / acetonitrile / 1 h

2: 85 percent / NH₃, CH₃OH / 24 h / 120 °C

3: H₂ / 10percent Pd/C / ethanol; H₂O / 5 h / 2585.7 Torr / Ambient temperature

4: 80 percent / pyridine / 0.75 h / Heating

5: 1.) conc. NH₄OH, 30percent aq. H₂O₂, 2.) NH₃ / 1.) 0 deg C, 40 min, 2.) 120 deg C, 12 h

6: 1.) Me₃SiCl, pyridine / 1.) 0 deg C, 30 min, 2.) RT, 3 h

7: 75 percent / pyridine / 4 °C

With pyridine; methanol; ammonium hydroxide; chloro-trimethyl-silane; ammonia; hydrogen; dihydrogen peroxide; sodium hydride; palladium on activated charcoal; In pyridine; ethanol; water; acetonitrile;
DOI:10.1021/ja00030a050

Reference yield:

: 138836-90-5
1-(2-deoxy-β-D-ribofuranosyl)-5-methyl-4-nitro-1H-pyrazole-3-carboxamide

: 138856-94-7
N-<2-<5-O--2-deoxy-β-D-ribofuranosyl>-3-methyl-7-oxo-2H-pyrazolo<4,3-d>pyrimidin-5-yl>-2-methylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 10percent Pd/C / ethanol; H₂O / 5 h / 2585.7 Torr / Ambient temperature

2: 80 percent / pyridine / 0.75 h / Heating

3: 1.) conc. NH₄OH, 30percent aq. H₂O₂, 2.) NH₃ / 1.) 0 deg C, 40 min, 2.) 120 deg C, 12 h

4: 1.) Me₃SiCl, pyridine / 1.) 0 deg C, 30 min, 2.) RT, 3 h

5: 75 percent / pyridine / 4 °C

With pyridine; ammonium hydroxide; chloro-trimethyl-silane; hydrogen; dihydrogen peroxide; palladium on activated charcoal; In pyridine; ethanol; water;
DOI:10.1021/ja00030a050