1-(5-chloro-2-methoxy-benzyl)-5-ethoxy-3-(4-trifluoromethyl-phenyl)-1H-[1,2,4]triazole

Base Information

• Chemical Name: 1-(5-chloro-2-methoxy-benzyl)-5-ethoxy-3-(4-trifluoromethyl-phenyl)-1H-[1,2,4]triazole
• CAS No.: 202823-02-7
• Molecular Formula: C₁₉H₁₇ClF₃N₃O₂
• Molecular Weight: 411.811

Synonyms:1-(5-chloro-2-methoxy-benzyl)-5-ethoxy-3-(4-trifluoromethyl-phenyl)-1H-[1,2,4]triazole

Chemical Property of 1-(5-chloro-2-methoxy-benzyl)-5-ethoxy-3-(4-trifluoromethyl-phenyl)-1H-[1,2,4]triazole

Chemical Property:

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Technology Process of 1-(5-chloro-2-methoxy-benzyl)-5-ethoxy-3-(4-trifluoromethyl-phenyl)-1H-[1,2,4]triazole

There total 2 articles about 1-(5-chloro-2-methoxy-benzyl)-5-ethoxy-3-(4-trifluoromethyl-phenyl)-1H-[1,2,4]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-ethoxy-5-[4-(trifluoromethyl)phenyl]-4H-1,2,4-triazole (202822-99-9) + 2-(bromomethyl)-4-chloro-1-methoxybenzene (58735-58-3) → 1-(5-chloro-2-methoxy-benzyl)-3-ethoxy-5-(4-trifluoromethyl-phenyl)-1H-[1,2,4]triazole + 1-(5-chloro-2-methoxy-benzyl)-5-ethoxy-3-(4-trifluoromethyl-phenyl)-1H-[1,2,4]triazole (202823-02-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 24 ℃; for 18h;

DOI:10.1021/jm061006n

Reference yield:

2-amino-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole (202823-23-2) → 1-(5-chloro-2-methoxy-benzyl)-5-ethoxy-3-(4-trifluoromethyl-phenyl)-1H-[1,2,4]triazole (202823-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.76 g / KOH / ethanol / 3 h / Heating

2: NaH / dimethylformamide / 18 h / 24 °C

With potassium hydroxide; sodium hydride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm061006n

Reference yield:

1-(5-chloro-2-methoxy-benzyl)-5-ethoxy-3-(4-trifluoromethyl-phenyl)-1H-[1,2,4]triazole (202823-02-7) → 2-(5-chloro-2-methoxy-benzyl)-5-(4-trifluoromethyl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one (202823-05-0)

Guidance literature:

With hydrogenchloride; In ethanol; for 1h; Heating;

DOI:10.1021/jm061006n

upstream raw materials:

3-ethoxy-5-[4-(trifluoromethyl)phenyl]-4H-1,2,4-triazole

2-(bromomethyl)-4-chloro-1-methoxybenzene

2-amino-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

Downstream raw materials:

2-(5-chloro-2-methoxy-benzyl)-5-(4-trifluoromethyl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

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