9-Methyl-10b-morpholin-4-yl-1-(4-nitro-phenyl)-3a,4,5,10b-tetrahydro-1H-6-thia-1,2,3-triaza-benzo[e]azulene

Base Information

• Chemical Name: 9-Methyl-10b-morpholin-4-yl-1-(4-nitro-phenyl)-3a,4,5,10b-tetrahydro-1H-6-thia-1,2,3-triaza-benzo[e]azulene
• CAS No.: 76867-52-2
• Molecular Formula: C₂₁H₂₃N₅O₃S
• Molecular Weight: 425.511

Synonyms:9-Methyl-10b-morpholin-4-yl-1-(4-nitro-phenyl)-3a,4,5,10b-tetrahydro-1H-6-thia-1,2,3-triaza-benzo[e]azulene

Chemical Property of 9-Methyl-10b-morpholin-4-yl-1-(4-nitro-phenyl)-3a,4,5,10b-tetrahydro-1H-6-thia-1,2,3-triaza-benzo[e]azulene

Chemical Property:

Purity/Quality:

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Technology Process of 9-Methyl-10b-morpholin-4-yl-1-(4-nitro-phenyl)-3a,4,5,10b-tetrahydro-1H-6-thia-1,2,3-triaza-benzo[e]azulene

There total 5 articles about 9-Methyl-10b-morpholin-4-yl-1-(4-nitro-phenyl)-3a,4,5,10b-tetrahydro-1H-6-thia-1,2,3-triaza-benzo[e]azulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-nitrophenyl azide (1516-60-5) + 4-(7-Methyl-2,3-dihydro-benzo[b]thiepin-5-yl)-morpholine (76867-41-9) → 9-Methyl-10b-morpholin-4-yl-1-(4-nitro-phenyl)-3a,4,5,10b-tetrahydro-1H-6-thia-1,2,3-triaza-benzo[e]azulene (76867-52-2)

Guidance literature:

In benzene; heating on a water bath;

DOI:10.1002/jhet.5570170738

Reference yield:

7-methyl-2,3,4,5-tetrahydrobenzothiepin-5-one (18850-47-0) → 9-Methyl-10b-morpholin-4-yl-1-(4-nitro-phenyl)-3a,4,5,10b-tetrahydro-1H-6-thia-1,2,3-triaza-benzo[e]azulene (76867-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / TiCl₄ / pentane; benzene / 24 h / Ambient temperature

2: 70 percent / benzene / heating on a water bath

With titanium tetrachloride; In pentane; benzene;

DOI:10.1002/jhet.5570170738

Reference yield:

Dimethyl-[9-methyl-1-(4-nitro-phenyl)-1,3a,4,5-tetrahydro-6-thia-1,2,3-triaza-benzo[e]azulen-10b-yl]-amine (76867-45-3) → 9-Methyl-10b-morpholin-4-yl-1-(4-nitro-phenyl)-3a,4,5,10b-tetrahydro-1H-6-thia-1,2,3-triaza-benzo[e]azulene (76867-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / Heating

2: 70 percent / benzene / heating on a water bath

In acetonitrile; benzene;

DOI:10.1002/jhet.5570170738

upstream raw materials:

4-nitrophenyl azide

4-(7-Methyl-2,3-dihydro-benzo[b]thiepin-5-yl)-morpholine

7-methyl-2,3,4,5-tetrahydrobenzothiepin-5-one

Dimethyl-[9-methyl-1-(4-nitro-phenyl)-1,3a,4,5-tetrahydro-6-thia-1,2,3-triaza-benzo[e]azulen-10b-yl]-amine

Downstream raw materials:

4-(7-Methyl-2,3-dihydro-benzo[b]thiepin-5-yl)-morpholine

7a-morpholin-4-yl-1-(4-nitro-phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzo[1,2,3]triazole

4-nitrophenyl azide

Dimethyl-[9-methyl-1-(4-nitro-phenyl)-1,3a,4,5-tetrahydro-6-thia-1,2,3-triaza-benzo[e]azulen-10b-yl]-amine

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