4-[7-(cis-4-methylcyclohexyloxy)-8-trifluoromethyl-naphthalen-2-ylmethyl]morpholine

Base Information

Chemical Name:4-[7-(cis-4-methylcyclohexyloxy)-8-trifluoromethyl-naphthalen-2-ylmethyl]morpholine
CAS No.:1543999-84-3
Molecular Formula:C₂₃H₂₈F₃NO₂
Molecular Weight:407.476
Hs Code.:

Synonyms:4-[7-(cis-4-methylcyclohexyloxy)-8-trifluoromethyl-naphthalen-2-ylmethyl]morpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[7-(cis-4-methylcyclohexyloxy)-8-trifluoromethyl-naphthalen-2-ylmethyl]morpholine

Chemical Property:

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Technology Process of 4-[7-(cis-4-methylcyclohexyloxy)-8-trifluoromethyl-naphthalen-2-ylmethyl]morpholine

There total 8 articles about 4-[7-(cis-4-methylcyclohexyloxy)-8-trifluoromethyl-naphthalen-2-ylmethyl]morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 110-91-8,99108-56-2
morpholine

: 1544009-11-1
methanesulfonic acid 7-(cis-4-methylcyclohexyloxy)-8-trifluoromethylnaphthalen-2-ylmethyl ester

: 1543999-84-3
4-[7-(cis-4-methylcyclohexyloxy)-8-trifluoromethyl-naphthalen-2-ylmethyl]morpholine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

Reference yield:

: 1544009-02-0
7-bromo-2-(cis-4-methylcyclohexyloxy)-1-trifluoromethylnaphthalene

: 1543999-84-3
4-[7-(cis-4-methylcyclohexyloxy)-8-trifluoromethyl-naphthalen-2-ylmethyl]morpholine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: 1 h / -78 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

With lithium aluminium tetrahydride; n-butyllithium; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1544009-05-3
7-(cis-4-methylcyclohexyloxy)-8-trifluoromethylnaphthalene-2-carbaldehyde

: 1543999-84-3
4-[7-(cis-4-methylcyclohexyloxy)-8-trifluoromethyl-naphthalen-2-ylmethyl]morpholine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

With lithium aluminium tetrahydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;