N-(2-(hex-5-yn-1-yloxy)benzyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

Base Information

Chemical Name:N-(2-(hex-5-yn-1-yloxy)benzyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide
CAS No.:1393589-46-2
Molecular Formula:C₂₃H₂₅NO₃S
Molecular Weight:395.522
Hs Code.:

Synonyms:N-(2-(hex-5-yn-1-yloxy)benzyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-(hex-5-yn-1-yloxy)benzyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

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Technology Process of N-(2-(hex-5-yn-1-yloxy)benzyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

There total 4 articles about N-(2-(hex-5-yn-1-yloxy)benzyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1393589-44-0
(2-(hex-5-yn-1-yloxy)phenyl)methanol

: 55022-46-3
4-methyl-N-prop-2-ynylbenzenesulfonamide

: 1393589-46-2
N-(2-(hex-5-yn-1-yloxy)benzyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 30h; Inert atmosphere;
DOI:10.1021/ol3020623

Reference yield:

: 76911-01-8
5-hexynyl p-toluenesulfonate

: 1393589-46-2
N-(2-(hex-5-yn-1-yloxy)benzyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / Inert atmosphere; Reflux

2: sodium tetrahydroborate / tetrahydrofuran / 0.17 h / Inert atmosphere

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 30 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol3020623

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1393589-46-2
N-(2-(hex-5-yn-1-yloxy)benzyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 30 h / 0 - 20 °C / Inert atmosphere

With dmap; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol3020623