(3Z,9Z,13E,15E)-1-Benzyloxy-5,18-bis-(tert-butyl-dimethyl-silanyloxy)-15-methoxy-3,10,13,16-tetramethyl-octadeca-3,9,13,15-tetraen-11-yn-8-ol

Base Information

Chemical Name:(3Z,9Z,13E,15E)-1-Benzyloxy-5,18-bis-(tert-butyl-dimethyl-silanyloxy)-15-methoxy-3,10,13,16-tetramethyl-octadeca-3,9,13,15-tetraen-11-yn-8-ol
CAS No.:863887-31-4
Molecular Formula:C₄₂H₇₀O₅Si₂
Molecular Weight:711.186
Hs Code.:

Synonyms:(3Z,9Z,13E,15E)-1-Benzyloxy-5,18-bis-(tert-butyl-dimethyl-silanyloxy)-15-methoxy-3,10,13,16-tetramethyl-octadeca-3,9,13,15-tetraen-11-yn-8-ol

Suppliers and Price of (3Z,9Z,13E,15E)-1-Benzyloxy-5,18-bis-(tert-butyl-dimethyl-silanyloxy)-15-methoxy-3,10,13,16-tetramethyl-octadeca-3,9,13,15-tetraen-11-yn-8-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3Z,9Z,13E,15E)-1-Benzyloxy-5,18-bis-(tert-butyl-dimethyl-silanyloxy)-15-methoxy-3,10,13,16-tetramethyl-octadeca-3,9,13,15-tetraen-11-yn-8-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3Z,9Z,13E,15E)-1-Benzyloxy-5,18-bis-(tert-butyl-dimethyl-silanyloxy)-15-methoxy-3,10,13,16-tetramethyl-octadeca-3,9,13,15-tetraen-11-yn-8-ol

There total 16 articles about (3Z,9Z,13E,15E)-1-Benzyloxy-5,18-bis-(tert-butyl-dimethyl-silanyloxy)-15-methoxy-3,10,13,16-tetramethyl-octadeca-3,9,13,15-tetraen-11-yn-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 863887-20-1
tert-Butyl-((3E,5E)-4-methoxy-3,6-dimethyl-octa-3,5-dien-7-ynyloxy)-dimethyl-silane

: 863887-19-8
(2Z,8Z)-11-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-2-iodo-9-methyl-undeca-2,8-dien-4-ol

: 863887-31-4
(3Z,9Z,13E,15E)-1-Benzyloxy-5,18-bis-(tert-butyl-dimethyl-silanyloxy)-15-methoxy-3,10,13,16-tetramethyl-octadeca-3,9,13,15-tetraen-11-yn-8-ol

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethylamine; at 20 ℃;
DOI:10.1246/cl.2005.1058

Reference yield:

: 863887-21-2
((Z)-4-Iodo-3-methyl-but-3-enyloxymethyl)-benzene

: 863887-31-4
(3Z,9Z,13E,15E)-1-Benzyloxy-5,18-bis-(tert-butyl-dimethyl-silanyloxy)-15-methoxy-3,10,13,16-tetramethyl-octadeca-3,9,13,15-tetraen-11-yn-8-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-BuLi / diethyl ether / -78 °C

1.2: 75 percent / diethyl ether

2.1: 100 percent / 2,6-lutidine / CH₂Cl₂ / -78 °C

3.1: 97 percent / Al₂O₃ / hexane / 20 °C

4.1: 82 percent / pyridinium dichromate; 4 A MS / CH₂Cl₂ / 20 °C

5.1: 94 percent / diethyl ether / -78 °C

6.1: Red-Al(R) / diethyl ether / 20 °C

6.2: 73 percent / I₂ / diethyl ether; tetrahydrofuran / 0 °C

7.1: 100 percent / Pd(Ph₃)4; CuI; Et₂NH / 20 °C

With 2,6-dimethylpyridine; aluminum oxide; copper(l) iodide; dipyridinium dichromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; diethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In diethyl ether; hexane; dichloromethane; 7.1: Sonogashira coupling reaction;
DOI:10.1246/cl.2005.1058

Reference yield:

: (2E,4E)-7-Hydroxy-4-methoxy-2,5-dimethyl-hepta-2,4-dienoic acid ethyl ester

: 863887-31-4
(3Z,9Z,13E,15E)-1-Benzyloxy-5,18-bis-(tert-butyl-dimethyl-silanyloxy)-15-methoxy-3,10,13,16-tetramethyl-octadeca-3,9,13,15-tetraen-11-yn-8-ol

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole / dimethylformamide / 20 °C

2: 82 percent / DIBAL-H / CH₂Cl₂ / -78 °C

3: 91 percent / MnO₂ / CH₂Cl₂ / 20 °C

4: 69 percent / K₂CO₃ / methanol / 20 °C

5: 100 percent / Pd(Ph₃)4; CuI; Et₂NH / 20 °C

With 1H-imidazole; manganese(IV) oxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisobutylaluminium hydride; potassium carbonate; diethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; 5: Sonogashira coupling reaction;
DOI:10.1246/cl.2005.1058