{(S)-2-[5-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-ylphenyl)methanone

Base Information

Chemical Name:{(S)-2-[5-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-ylphenyl)methanone
CAS No.:1597522-78-5
Molecular Formula:C₂₃H₂₁ClN₆O₂
Molecular Weight:448.912
Hs Code.:

Synonyms:{(S)-2-[5-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-ylphenyl)methanone

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Chemical Property of {(S)-2-[5-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-ylphenyl)methanone

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Technology Process of {(S)-2-[5-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-ylphenyl)methanone

There total 5 articles about {(S)-2-[5-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-ylphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 956317-36-5
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

: 1597529-15-1
5-(3-chloro-2-methylphenyl)-3-(S)-pyrrolidin-2-yl-[1,2,4]oxadiazole

: 1597522-78-5
{(S)-2-[5-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-ylphenyl)methanone

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1597528-85-2
(S)-2-[5-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

: 1597522-78-5
{(S)-2-[5-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-ylphenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 681239-91-8
(S)-2-(N-hydroxycarbamimidoyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1597522-78-5
{(S)-2-[5-(3-chloro-2-methylphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-ylphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate

2: 1,4-dioxane / 90 °C

3: trifluoroacetic acid / dichloromethane / 1 h

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;