(1S,3'S,5'S)-N-(2-cyclohexyl-1-(3-isopropyl-2-oxo-2,3,4,5-tetrahydrofuran-5-yl)ethyl)-(1S)-(1-((4-(methoxymethoxy)piperidin-1-yl)carbonyl)-2-phenylethyl)-L-norleucinamide

Base Information

Chemical Name:(1S,3'S,5'S)-N-(2-cyclohexyl-1-(3-isopropyl-2-oxo-2,3,4,5-tetrahydrofuran-5-yl)ethyl)-(1S)-(1-((4-(methoxymethoxy)piperidin-1-yl)carbonyl)-2-phenylethyl)-L-norleucinamide
CAS No.:161316-40-1
Molecular Formula:C₃₇H₅₉N₃O₆
Molecular Weight:641.892
Hs Code.:

(1S,3'S,5'S)-N-(2-cyclohexyl-1-(3-isopropyl-2-oxo-2,3,4,5-tetrahydrofuran-5-yl)ethyl)-(1S)-(1-((4-(methoxymethoxy)piperidin-1-yl)carbonyl)-2-phenylethyl)-L-norleucinamide

Synonyms:(1S,3'S,5'S)-N-(2-cyclohexyl-1-(3-isopropyl-2-oxo-2,3,4,5-tetrahydrofuran-5-yl)ethyl)-(1S)-(1-((4-(methoxymethoxy)piperidin-1-yl)carbonyl)-2-phenylethyl)-L-norleucinamide

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Chemical Property of (1S,3'S,5'S)-N-(2-cyclohexyl-1-(3-isopropyl-2-oxo-2,3,4,5-tetrahydrofuran-5-yl)ethyl)-(1S)-(1-((4-(methoxymethoxy)piperidin-1-yl)carbonyl)-2-phenylethyl)-L-norleucinamide

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Technology Process of (1S,3'S,5'S)-N-(2-cyclohexyl-1-(3-isopropyl-2-oxo-2,3,4,5-tetrahydrofuran-5-yl)ethyl)-(1S)-(1-((4-(methoxymethoxy)piperidin-1-yl)carbonyl)-2-phenylethyl)-L-norleucinamide

There total 2 articles about (1S,3'S,5'S)-N-(2-cyclohexyl-1-(3-isopropyl-2-oxo-2,3,4,5-tetrahydrofuran-5-yl)ethyl)-(1S)-(1-((4-(methoxymethoxy)piperidin-1-yl)carbonyl)-2-phenylethyl)-L-norleucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125816-10-6
<3S-<3α,5β(R^*)>>-5-(2-Cyclohexyl-1-aminoethyl)dihydro-3-isopropyl-2(3H)-furanone

: 140660-69-1
(2S,4S)-3-aza-2-butyl-4-<<4-(1,3-dioxabutyl)piperidin-1-yl>carbonyl>-5-phenylpentanoic acid

: 161316-40-1
(1S,3'S,5'S)-N-(2-cyclohexyl-1-(3-isopropyl-2-oxo-2,3,4,5-tetrahydrofuran-5-yl)ethyl)-(1S)-(1-((4-(methoxymethoxy)piperidin-1-yl)carbonyl)-2-phenylethyl)-L-norleucinamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at -23 - 20 ℃; for 18h; Yield given;
DOI:10.1021/jm00045a003

Reference yield:

: 124032-36-6
(3S,5S)-5-[(1S)-1-(t-butoxycarbonyl)amino-2-cyclohexylethyl]-3-isopropyldihydrofuran-2(3H)-one

: 161316-40-1
(1S,3'S,5'S)-N-(2-cyclohexyl-1-(3-isopropyl-2-oxo-2,3,4,5-tetrahydrofuran-5-yl)ethyl)-(1S)-(1-((4-(methoxymethoxy)piperidin-1-yl)carbonyl)-2-phenylethyl)-L-norleucinamide

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂ / 4 h / 0 °C

2: HOBt hydrate, 4-methylmorpholine, EDC / dimethylformamide / 18 h / -23 - 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a003