dimethyl 4,5,8,9-tetrahydro-1,1-dimethyl-4-phenylbenzo[c]oxepine-7,7(1H,3H,6H)-dicarboxylate

Base Information

Chemical Name:dimethyl 4,5,8,9-tetrahydro-1,1-dimethyl-4-phenylbenzo[c]oxepine-7,7(1H,3H,6H)-dicarboxylate
CAS No.:1303559-75-2
Molecular Formula:C₂₂H₂₈O₅
Molecular Weight:372.461
Hs Code.:

Synonyms:dimethyl 4,5,8,9-tetrahydro-1,1-dimethyl-4-phenylbenzo[c]oxepine-7,7(1H,3H,6H)-dicarboxylate

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Chemical Property of dimethyl 4,5,8,9-tetrahydro-1,1-dimethyl-4-phenylbenzo[c]oxepine-7,7(1H,3H,6H)-dicarboxylate

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Technology Process of dimethyl 4,5,8,9-tetrahydro-1,1-dimethyl-4-phenylbenzo[c]oxepine-7,7(1H,3H,6H)-dicarboxylate

There total 2 articles about dimethyl 4,5,8,9-tetrahydro-1,1-dimethyl-4-phenylbenzo[c]oxepine-7,7(1H,3H,6H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1303559-48-9
2-((tetrahydro-4-phenylfuran-2-yl)methyl)-2-(4-methylpenta-2,3-dienyl)-malonic acid dimethyl ester

: 1303559-75-2
dimethyl 4,5,8,9-tetrahydro-1,1-dimethyl-4-phenylbenzo[c]oxepine-7,7(1H,3H,6H)-dicarboxylate

: rac-(3S,5S,10S)-3-acetoxymethyl-10-isopropenyl-1-oxa-spiro[4.5]decane-7,7-dicarboxylic acid dimethyl ester

Guidance literature:: With (2,4-di-^tBu-C₆H₃O)₃PAu(PhCN)SbF₆; In dichloromethane; at 20 ℃; for 2h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja202336p

Reference yield:

: 1303559-47-8
dimethyl 2-((tetrahydro-4-phenylfuran-2-yl)methyl)malonate

: 1303559-75-2
dimethyl 4,5,8,9-tetrahydro-1,1-dimethyl-4-phenylbenzo[c]oxepine-7,7(1H,3H,6H)-dicarboxylate

: rac-(3S,5S,10S)-3-acetoxymethyl-10-isopropenyl-1-oxa-spiro[4.5]decane-7,7-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: (2,4-di-^tBu-C₆H₃O)₃PAu(PhCN)SbF₆ / dichloromethane / 2 h / 20 °C / Inert atmosphere

With (2,4-di-^tBu-C₆H₃O)₃PAu(PhCN)SbF₆; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja202336p