(2R,3S,4S,6S)-4-benzyloxy-7-(tert-butyldiphenylsiloxy)-2,6-dimethyl-5-methoxymethoxyheptanal

Base Information

Chemical Name:(2R,3S,4S,6S)-4-benzyloxy-7-(tert-butyldiphenylsiloxy)-2,6-dimethyl-5-methoxymethoxyheptanal
CAS No.:623938-88-5
Molecular Formula:C₃₄H₄₆O₅Si
Molecular Weight:562.822
Hs Code.:

Synonyms:(2R,3S,4S,6S)-4-benzyloxy-7-(tert-butyldiphenylsiloxy)-2,6-dimethyl-5-methoxymethoxyheptanal

Suppliers and Price of (2R,3S,4S,6S)-4-benzyloxy-7-(tert-butyldiphenylsiloxy)-2,6-dimethyl-5-methoxymethoxyheptanal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S,4S,6S)-4-benzyloxy-7-(tert-butyldiphenylsiloxy)-2,6-dimethyl-5-methoxymethoxyheptanal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S,4S,6S)-4-benzyloxy-7-(tert-butyldiphenylsiloxy)-2,6-dimethyl-5-methoxymethoxyheptanal

There total 6 articles about (2R,3S,4S,6S)-4-benzyloxy-7-(tert-butyldiphenylsiloxy)-2,6-dimethyl-5-methoxymethoxyheptanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: (2S,4S,5S,6R)-4-Benzyloxy-7-(tert-butyl-diphenyl-silanyloxy)-5-methoxymethoxy-2,6-dimethyl-heptan-1-ol

: 623938-88-5
(2R,3S,4S,6S)-4-benzyloxy-7-(tert-butyldiphenylsiloxy)-2,6-dimethyl-5-methoxymethoxyheptanal

Guidance literature:: With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; bisacetoxybromate(I) resin; In dichloromethane; at 40 ℃; for 0.5h;
DOI:10.1002/adsc.200202208

Reference yield: 96.0%

: (2S,5S,6R)-4-Benzyloxy-7-(tert-butyl-diphenyl-silanyloxy)-5-methoxymethoxy-2,6-dimethyl-heptan-1-ol

: 623938-88-5
(2R,3S,4S,6S)-4-benzyloxy-7-(tert-butyldiphenylsiloxy)-2,6-dimethyl-5-methoxymethoxyheptanal

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; resin-CH₂-N(Me)3(+)*Br(OAc)2(-); In dichloromethane; at 50 ℃; for 2h;
DOI:10.1016/j.tetlet.2004.04.056

Reference yield:

: 91751-24-5,92817-88-4,123284-89-9,112897-04-8
(R)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropanal

: 623938-88-5
(2R,3S,4S,6S)-4-benzyloxy-7-(tert-butyldiphenylsiloxy)-2,6-dimethyl-5-methoxymethoxyheptanal

Guidance literature:: Multi-step reaction with 7 steps

1.1: LDA / tetrahydrofuran / 0.17 h / -110 °C

1.2: 82 percent / tetrahydrofuran

2.1: KOtBu / tetrahydrofuran / 0.25 h / 0 °C

2.2: 86 percent / AD-mix α; MeSO2NH2 / tetrahydrofuran; H2O; 2-methyl-propan-2-ol

3.1: 83 percent / iPrNEt₂; 4-DMAP / CH₂Cl₂ / 40 °C

4.1: dibal-H / CH₂Cl₂; toluene / -78 - 20 °C

4.2: resin-CH₂-N(Me)3(+)*Br(OAc)2(-); TEMPO / CH₂Cl₂ / 2 h / 50 °C

5.1: tBuLi; MgBr₂*Et₂O / diethyl ether; pentane / -78 °C

5.2: diethyl ether; pentane / 0.5 h

5.3: 62 percent / Bu₄NI; NaH / 8 h / 70 °C

6.1: 85 percent / CSA / CH₂Cl₂ / 20 °C

7.1: 96 percent / resin-CH₂-N(Me)3(+)*Br(OAc)2(-); TEMPO / CH₂Cl₂ / 2 h / 50 °C

With dmap; 2,2,6,6-tetramethyl-piperidine-N-oxyl; N,N-diethyl-N-isopropylamine; resin-CH₂-N(Me)3(+)*Br(OAc)2(-); camphor-10-sulfonic acid; potassium tert-butylate; tert.-butyl lithium; diisobutylaluminium hydride; magnesium bromide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; pentane;
DOI:10.1016/j.tetlet.2004.04.056