9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine

Base Information

• Chemical Name: 9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine
• CAS No.: 82410-31-9
• Molecular Formula: C₂₃H₂₅N₅O₄
• Molecular Weight: 435.483

Synonyms:9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine

Chemical Property of 9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine

Chemical Property:

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Technology Process of 9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine

There total 14 articles about 9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N2-acetyl-9-<<1,3-bis(benzyloxy)-2-propoxy>methyl>guanine (82410-30-8) → 9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine (82410-31-9)

Guidance literature:

With pyridine; ammonium hydroxide; at 55 ℃; for 15h;

DOI:10.1139/v82-430

Reference yield: 95.0%

'N-7-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>-2-amino-6-chloropurine (93834-92-5) → 9-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>guanine (82410-31-9)

Guidance literature:

With sodium hydroxide; In methanol; water; for 1.5h; reflux;

DOI:10.1139/v84-459

Reference yield: 88.0%

7-(2-Benzyloxy-1-benzyloxymethyl-ethoxymethyl)-6-methoxy-7H-purin-2-ylamine (93834-93-6) → 9-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>guanine (82410-31-9)

Guidance literature:

With sodium hydroxide; In methanol; water; for 1.5h; reflux;

DOI:10.1139/v84-459

upstream raw materials:

2-amino-1,9-dihydro-6H-purin-6-one

1,3-dibenzyloxy-2-(chloromethoxy)propane

N²-acetyl-9-<<1,3-bis(benzyloxy)-2-propoxy>methyl>guanine

9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>-methyl>-6-chloroguanine

Downstream raw materials:

ganciclovir

9-(2-Benzyloxy-1-benzyloxymethyl-ethoxymethyl)-3,9-dihydro-purine-2,6-dione

N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-fluoro-2-propoxy]methyl]guanine

9-[({1-hydroxy-3-[(4-methoxyphenyl)-diphenylmethoxy]propan-2-yl}oxy)methyl]-2-{[(4-methoxyphenyl)diphenylmethyl]amino}-6,9-dihydro-1H-purin-6-one

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