4-(2-(N-methylaminoformoxyl)-4-(6-methoxyquinolinyl)oxy)aniline

Base Information

• Chemical Name: 4-(2-(N-methylaminoformoxyl)-4-(6-methoxyquinolinyl)oxy)aniline
• CAS No.: 1220892-81-8
• Molecular Formula: C₁₈H₁₇N₃O₃
• Molecular Weight: 323.351
• Mol file: 1220892-81-8.mol

Synonyms:4-(2-(N-methylaminoformoxyl)-4-(6-methoxyquinolinyl)oxy)aniline

Chemical Property of 4-(2-(N-methylaminoformoxyl)-4-(6-methoxyquinolinyl)oxy)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(N-methylaminoformoxyl)-4-(6-methoxyquinolinyl)oxy)aniline

There total 3 articles about 4-(2-(N-methylaminoformoxyl)-4-(6-methoxyquinolinyl)oxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-6-methoxy-N-methyl-2-quinoline carboxamide (1220892-80-7) + 4-amino-phenol (123-30-8) → 4-(2-(N-methylaminoformoxyl)-4-(6-methoxyquinolinyl)oxy)aniline (1220892-81-8)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 70 ℃; for 8h; Inert atmosphere;

Reference yield:

6-methoxykynurenic acid (91092-95-4) → 4-(2-(N-methylaminoformoxyl)-4-(6-methoxyquinolinyl)oxy)aniline (1220892-81-8)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 17 h / Reflux

2: ethanol / 36 h / 0 °C

3: potassium tert-butylate / N,N-dimethyl-formamide / 8 h / 70 °C / Inert atmosphere

With thionyl chloride; potassium tert-butylate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

4-chloro-6-methoxyquinolinyl-2-carbonyl chloride (1220892-79-4) → 4-(2-(N-methylaminoformoxyl)-4-(6-methoxyquinolinyl)oxy)aniline (1220892-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 36 h / 0 °C

2: potassium tert-butylate / N,N-dimethyl-formamide / 8 h / 70 °C / Inert atmosphere

With potassium tert-butylate; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

4-chloro-6-methoxy-N-methyl-2-quinoline carboxamide

4-amino-phenol

6-methoxykynurenic acid

4-chloro-6-methoxyquinolinyl-2-carbonyl chloride

Downstream raw materials:

N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylaminoformoxyl)-4-(6-methoxyquinolinyl)oxy)phenyl)urea

N-(4-fluoro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylaminoformoxyl)-4-(6-methoxyquinolinyl)oxy)phenyl)urea

N-(4-bromo-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylaminoformoxyl)-4-(6-methoxyquinolinyl)oxy)phenyl)urea