3-[8-(2,6-difluoro-phenyl)-2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-propyl-benzamide

Base Information

Chemical Name:3-[8-(2,6-difluoro-phenyl)-2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-propyl-benzamide
CAS No.:911490-27-2
Molecular Formula:C₂₅H₂₂F₂N₄O₄S
Molecular Weight:512.537
Hs Code.:

Synonyms:3-[8-(2,6-difluoro-phenyl)-2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-propyl-benzamide

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Chemical Property of 3-[8-(2,6-difluoro-phenyl)-2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-propyl-benzamide

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Technology Process of 3-[8-(2,6-difluoro-phenyl)-2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-propyl-benzamide

There total 10 articles about 3-[8-(2,6-difluoro-phenyl)-2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-propyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[8-(2,6-difluoro-phenyl)-2-methylsulfanyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-propyl-benzamide

: 911490-27-2
3-[8-(2,6-difluoro-phenyl)-2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-propyl-benzamide

Guidance literature:: With Oxone; In water; acetonitrile; at 40 ℃;

Reference yield:

: 444605-13-4
4-Chloro-6-(2,6-difluoro-phenylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde

: 911490-27-2
3-[8-(2,6-difluoro-phenyl)-2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-propyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 0.5 h / 160 °C / Microwave irradiation

2: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; isopropyl alcohol / 80 °C

3: Oxone / water; acetonitrile / 40 °C

With Oxone; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; 2: Suzuki Coupling;

Reference yield:

: 911110-48-0
4-chloro-2-methylsulfanyl-8-(2,6-difluoro-phenyl)-8H-pyrido[2,3-d]pyrimidin-7-one

: 911490-27-2
3-[8-(2,6-difluoro-phenyl)-2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-propyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; isopropyl alcohol / 80 °C

2: Oxone / water; acetonitrile / 40 °C

With Oxone; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; isopropyl alcohol; acetonitrile; 1: Suzuki Coupling;