2(1H)-Isoquinolinecarboxylic acid, 1-[(4-amino-3-iodophenyl)methyl]-6,7-bis[(ethoxycarbonyl)oxy]-3,4-dihydro-, 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:2(1H)-Isoquinolinecarboxylic acid, 1-[(4-amino-3-iodophenyl)methyl]-6,7-bis[(ethoxycarbonyl)oxy]-3,4-dihydro-, 9H-fluoren-9-ylmethyl ester
CAS No.:880475-02-5
Molecular Formula:C37H35 I N2 O8
Molecular Weight:0
Hs Code.:
Mol file:880475-02-5.mol

Synonyms:2(1H)-Isoquinolinecarboxylic acid, 1-[(4-amino-3-iodophenyl)methyl]-6,7-bis[(ethoxycarbonyl)oxy]-3,4-dihydro-, 9H-fluoren-9-ylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2(1H)-Isoquinolinecarboxylic acid, 1-[(4-amino-3-iodophenyl)methyl]-6,7-bis[(ethoxycarbonyl)oxy]-3,4-dihydro-, 9H-fluoren-9-ylmethyl ester

Chemical Property:

PSA：126.62000
LogP:8.55410

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2(1H)-Isoquinolinecarboxylic acid, 1-[(4-amino-3-iodophenyl)methyl]-6,7-bis[(ethoxycarbonyl)oxy]-3,4-dihydro-, 9H-fluoren-9-ylmethyl ester

There total 6 articles about 2(1H)-Isoquinolinecarboxylic acid, 1-[(4-amino-3-iodophenyl)methyl]-6,7-bis[(ethoxycarbonyl)oxy]-3,4-dihydro-, 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 924651-73-0
1-(4-amino-benzyl)-6,7-bis-ethoxycarbonyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 9H-fluoren-9-ylmethyl ester

: 880475-02-5
1-(4-amino-3-iodobenzyl)-6,7-bis(ethoxycarbonyloxy)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate; In methanol; dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2005.12.027

Reference yield:

: 880474-96-4
2-[(9H-fluoren-9-yl)methoxycarbonyl]-6,7-dimethoxy-1-(4-nitrobenzyl)-1,2,3,4-tetrahydroisoquinoline

: 880475-02-5
1-(4-amino-3-iodobenzyl)-6,7-bis(ethoxycarbonyloxy)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / BBr₃ / CH₂Cl₂ / cooling

2: 95 percent / pyridine / CH₂Cl₂ / 20 °C

3: 99 percent / H₂ / Pd-C / ethyl acetate / 4 h / 3102.89 Torr

4: 64 percent / benzyltrimethylammonium dichloroiodate; CaCO₃ / methanol; CH₂Cl₂ / 2 h / 20 °C

With pyridine; hydrogen; boron tribromide; N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2005.12.027

Reference yield:

: 880474-98-6
2-[(9H-fluoren-9-yl)methoxycarbonyl]-6,7-dihydroxy-1-(4-nitrobenzyl)-1,2,3,4-tetrahydroisoquinoline

: 880475-02-5
1-(4-amino-3-iodobenzyl)-6,7-bis(ethoxycarbonyloxy)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / pyridine / CH₂Cl₂ / 20 °C

2: 99 percent / H₂ / Pd-C / ethyl acetate / 4 h / 3102.89 Torr

3: 64 percent / benzyltrimethylammonium dichloroiodate; CaCO₃ / methanol; CH₂Cl₂ / 2 h / 20 °C

With pyridine; hydrogen; N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2005.12.027