N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-N₂-(3,5-dimethyl)phenyl-5-fluoro-2,4-pyrimidinediamine

Base Information

• Chemical Name: N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-N₂-(3,5-dimethyl)phenyl-5-fluoro-2,4-pyrimidinediamine
• CAS No.: 1019855-81-2
• Molecular Formula: C₂₂H₂₄FN₅O₂S
• Molecular Weight: 441.529

Synonyms:N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-N₂-(3,5-dimethyl)phenyl-5-fluoro-2,4-pyrimidinediamine

Chemical Property of N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-N₂-(3,5-dimethyl)phenyl-5-fluoro-2,4-pyrimidinediamine

Chemical Property:

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Technology Process of N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-N₂-(3,5-dimethyl)phenyl-5-fluoro-2,4-pyrimidinediamine

There total 4 articles about N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-N₂-(3,5-dimethyl)phenyl-5-fluoro-2,4-pyrimidinediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-N4-(4-cyclopropylsulfonylaminomethyl)phenyl-5-fluoro-4-pyrimidineamine (1019855-84-5) + 3,5-dimethylaminoaniline (108-69-0) → N4-(4-cyclopropylsulfonylaminomethyl)phenyl-N2-(3,5-dimethyl)phenyl-5-fluoro-2,4-pyrimidinediamine (1019855-81-2)

Guidance literature:

With trifluoroacetic acid; In isopropyl alcohol; at 100 ℃;

Reference yield:

N-cyclopropylsulfonyl-4-nitrobenzylamine (1019855-82-3) → N4-(4-cyclopropylsulfonylaminomethyl)phenyl-N2-(3,5-dimethyl)phenyl-5-fluoro-2,4-pyrimidinediamine (1019855-81-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 2068.65 Torr

2: methanol; water / 20 °C

3: trifluoroacetic acid / isopropyl alcohol / 100 °C

With hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; water; isopropyl alcohol;

Reference yield:

4-nitrobenzylamine hydrochloride (18600-42-5) → N4-(4-cyclopropylsulfonylaminomethyl)phenyl-N2-(3,5-dimethyl)phenyl-5-fluoro-2,4-pyrimidinediamine (1019855-81-2)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 2068.65 Torr

3: methanol; water / 20 °C

4: trifluoroacetic acid / isopropyl alcohol / 100 °C

With hydrogen; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; water; isopropyl alcohol;

upstream raw materials:

2-chloro-N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-5-fluoro-4-pyrimidineamine

3,5-dimethylaminoaniline

N-cyclopropylsulfonyl-4-aminobenzylamine

N-cyclopropylsulfonyl-4-nitrobenzylamine

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