4-(3-Nitrophenyl)benzyl alcohol

Base Information

• Chemical Name: 4-(3-Nitrophenyl)benzyl alcohol
• CAS No.: 880158-11-2
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.235
• Hs Code.: 2906299090
• Mol file: 880158-11-2.mol

Synonyms:(3'-Nitro-1,1'-biphenyl-4-yl)methanol

Chemical Property of 4-(3-Nitrophenyl)benzyl alcohol

Chemical Property:

• PSA: 66.05000
• LogP: 3.27730

Purity/Quality:

98%min ^*data from raw suppliers

(3'-Nitro[1,1'-biphenyl]-4-yl)methanol >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-Nitrophenyl)benzyl alcohol

There total 3 articles about 4-(3-Nitrophenyl)benzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-bromobenzenemethanol (873-75-6) + m-nitrobenzene boronic acid (13331-27-6) → 4-hydroxymethyl-3'-nitrobiphenyl (880158-11-2)

Guidance literature:

With tetra-butylammonium acetate; Pd EnCat-30^TM; In ethanol; for 0.25h; microwave irradiation;

DOI:10.1002/chem.200501400

Reference yield:

4-iodo-benzyl alcohol (18282-51-4) + m-nitrobenzene boronic acid (13331-27-6) → 4-hydroxymethyl-3'-nitrobiphenyl (880158-11-2)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; triethylamine; In water; at 60 ℃; for 6h; Inert atmosphere;

DOI:10.1039/d1ra05315a

Reference yield:

→ 4-hydroxymethyl-3'-nitrobiphenyl (880158-11-2)

Guidance literature:

upstream raw materials:

4-bromobenzenemethanol

m-nitrobenzene boronic acid

4-iodo-benzyl alcohol

Refernces

• 1、 -. "Purinenucleoside derivative modified in 8-position and medical use thereof". Page/Page column 35. . Retrieved 2010/11/28.