7-chloro-1-isopropyl-3-methyl-3-(4-methyl-benzyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Base Information

Chemical Name:7-chloro-1-isopropyl-3-methyl-3-(4-methyl-benzyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
CAS No.:608538-72-3
Molecular Formula:C₂₇H₂₇ClN₂O
Molecular Weight:430.977
Hs Code.:

7-chloro-1-isopropyl-3-methyl-3-(4-methyl-benzyl)-5-phenyl-1,3-dihydro-benzo[<i>e</i>][1,4]diazepin-2-one

Synonyms:7-chloro-1-isopropyl-3-methyl-3-(4-methyl-benzyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

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Chemical Property of 7-chloro-1-isopropyl-3-methyl-3-(4-methyl-benzyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

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Technology Process of 7-chloro-1-isopropyl-3-methyl-3-(4-methyl-benzyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

There total 2 articles about 7-chloro-1-isopropyl-3-methyl-3-(4-methyl-benzyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 104-81-4
4-Methylbenzyl bromide

: 608538-67-6
7-chloro-1-isopropyl-3-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 608538-72-3
7-chloro-1-isopropyl-3-methyl-3-(4-methyl-benzyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: 7-chloro-1-isopropyl-3-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; hexane; for 0.25h;

With n-butyllithium; In tetrahydrofuran; hexane; for 0.25h;

4-Methylbenzyl bromide; In tetrahydrofuran; hexane; at -78 ℃; for 6h;
DOI:10.1021/ja0365781

Reference yield:

: 39200-48-1
(S)-7-chloro-1,3-dihydro-3-methyl-5-phenyl-2H-1,4-benzodiazepine-2-one

: 608538-72-3
7-chloro-1-isopropyl-3-methyl-3-(4-methyl-benzyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

1.2: 82 percent / tetrahydrofuran / 0.17 h / 0 °C

2.1: HMPA; LDA / tetrahydrofuran; hexane / 0.25 h

2.2: n-BuLi / tetrahydrofuran; hexane / 0.25 h

2.3: 68 percent / tetrahydrofuran; hexane / 6 h / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1021/ja0365781

Reference yield: 62.0%

: 608538-72-3
7-chloro-1-isopropyl-3-methyl-3-(4-methyl-benzyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: (R)-α-methyl-(4-methylphenyl)alanine

Guidance literature:: 7-chloro-1-isopropyl-3-methyl-3-(4-methyl-benzyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; With hydrogenchloride; for 72h; Heating;

With methyloxirane; In ethanol; for 0.5h; Heating;
DOI:10.1021/ja0365781