Acetic acid ((3S,3aR,4S,6aS,6bS)-5-acetyl-4-benzyl-3-methyl-2-methylene-6-oxo-1-vinyl-octahydro-5-aza-cyclopropa[e]inden-6a-yl)-((R)-5-oxo-tetrahydro-thiopyran-2-yl)-methyl ester

Base Information

Chemical Name:Acetic acid ((3S,3aR,4S,6aS,6bS)-5-acetyl-4-benzyl-3-methyl-2-methylene-6-oxo-1-vinyl-octahydro-5-aza-cyclopropa[e]inden-6a-yl)-((R)-5-oxo-tetrahydro-thiopyran-2-yl)-methyl ester
CAS No.:114634-54-7
Molecular Formula:C₃₀H₃₅NO₅S
Molecular Weight:521.678
Hs Code.:

Acetic acid ((3S,3aR,4S,6aS,6bS)-5-acetyl-4-benzyl-3-methyl-2-methylene-6-oxo-1-vinyl-octahydro-5-aza-cyclopropa[e]inden-6a-yl)-((R)-5-oxo-tetrahydro-thiopyran-2-yl)-methyl ester

Synonyms:Acetic acid ((3S,3aR,4S,6aS,6bS)-5-acetyl-4-benzyl-3-methyl-2-methylene-6-oxo-1-vinyl-octahydro-5-aza-cyclopropa[e]inden-6a-yl)-((R)-5-oxo-tetrahydro-thiopyran-2-yl)-methyl ester

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Chemical Property of Acetic acid ((3S,3aR,4S,6aS,6bS)-5-acetyl-4-benzyl-3-methyl-2-methylene-6-oxo-1-vinyl-octahydro-5-aza-cyclopropa[e]inden-6a-yl)-((R)-5-oxo-tetrahydro-thiopyran-2-yl)-methyl ester

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Technology Process of Acetic acid ((3S,3aR,4S,6aS,6bS)-5-acetyl-4-benzyl-3-methyl-2-methylene-6-oxo-1-vinyl-octahydro-5-aza-cyclopropa[e]inden-6a-yl)-((R)-5-oxo-tetrahydro-thiopyran-2-yl)-methyl ester

There total 7 articles about Acetic acid ((3S,3aR,4S,6aS,6bS)-5-acetyl-4-benzyl-3-methyl-2-methylene-6-oxo-1-vinyl-octahydro-5-aza-cyclopropa[e]inden-6a-yl)-((R)-5-oxo-tetrahydro-thiopyran-2-yl)-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 114634-52-5
Acetic acid [(1R,3aR,4R,7R,7aS)-2-acetyl-1-benzyl-4-((E)-3-chloro-propenyl)-7-methyl-3-oxo-6-trimethylsilanylmethyl-1,2,3,4,7,7a-hexahydro-isoindol-3a-yl]-((S)-5-oxo-tetrahydro-thiopyran-2-yl)-methyl ester

: 114634-54-7
Acetic acid ((3S,3aR,4S,6aS,6bS)-5-acetyl-4-benzyl-3-methyl-2-methylene-6-oxo-1-vinyl-octahydro-5-aza-cyclopropa[e]inden-6a-yl)-((R)-5-oxo-tetrahydro-thiopyran-2-yl)-methyl ester

: 114634-53-6
C₃₃H₄₃NO₅SSi

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; Heating;
DOI:10.1021/ja00222a047

Reference yield: 65.0%

: 114634-52-5,119324-87-7
Acetic acid (R)-[(1R,3aR,4R,7R,7aS)-2-acetyl-1-benzyl-4-((E)-3-chloro-propenyl)-7-methyl-3-oxo-6-trimethylsilanylmethyl-1,2,3,4,7,7a-hexahydro-isoindol-3a-yl]-((S)-5-oxo-tetrahydro-thiopyran-2-yl)-methyl ester

: 114634-54-7,127419-79-8
Acetic acid (S)-((3S,3aR,4S,6aS,6bS)-5-acetyl-4-benzyl-3-methyl-2-methylene-6-oxo-1-vinyl-octahydro-5-aza-cyclopropa[e]inden-6a-yl)-((R)-5-oxo-tetrahydro-thiopyran-2-yl)-methyl ester

: 114634-53-6,127354-65-8
C₃₃H₄₃NO₅SSi

: 114634-53-6,127354-65-8
C₃₃H₄₃NO₅SSi

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; at 68 - 70 ℃; for 17h;
DOI:10.1021/ja00167a036

Reference yield:

: 127354-63-6
Acetic acid (R)-[(1R,3aR,4R,7R,7aS)-2-acetyl-1-benzyl-4-((E)-3-hydroxy-propenyl)-7-methyl-3-oxo-6-trimethylsilanylmethyl-1,2,3,4,7,7a-hexahydro-isoindol-3a-yl]-((S)-5-oxo-tetrahydro-thiopyran-2-yl)-methyl ester

: 114634-54-7,127419-79-8
Acetic acid (S)-((3S,3aR,4S,6aS,6bS)-5-acetyl-4-benzyl-3-methyl-2-methylene-6-oxo-1-vinyl-octahydro-5-aza-cyclopropa[e]inden-6a-yl)-((R)-5-oxo-tetrahydro-thiopyran-2-yl)-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / tri-n-butylphosphine, carbon tetrachloride / 0.08 h

2: 9 percent / NaI, K₂CO₃ / acetonitrile / 17 h / 68 - 70 °C

With tetrachloromethane; tributylphosphine; potassium carbonate; sodium iodide; In acetonitrile;
DOI:10.1021/ja00167a036