(2S,4R)-4-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester

Base Information

• Chemical Name: (2S,4R)-4-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester
• CAS No.: 1201986-73-3
• Molecular Formula: C₂₃H₂₄N₄O₅
• Molecular Weight: 436.467

Synonyms:(2S,4R)-4-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester

Chemical Property of (2S,4R)-4-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester

Chemical Property:

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Technology Process of (2S,4R)-4-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester

There total 1 articles about (2S,4R)-4-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-hydroxy-3,4-dihydrobenzotriazine-4-one (28230-32-2) + (2S,4R)-1-(tert-butoxycarbonyl)-4-phenyl-2-pyrrolidinecarboxylic acid (336818-78-1,158567-91-0) → (2S,4R)-4-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester (1201986-73-3)

Guidance literature:

With diisopropyl-carbodiimide; In tetrahydrofuran; at 0 - 25 ℃; Product distribution / selectivity;

Reference yield: 88.0%

(2S,4R)-4-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester (1201986-73-3) + (-)-(R)-3-Phenylpyrrolidine (61586-46-7) → (2S,4R)-tert-butyl-4-phenyl-2-((R)-3-phenylpyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate (1201986-77-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 18 - 25 ℃; for 16h;

Reference yield: 88.0%

(2S,4R)-4-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester (1201986-73-3) + rac-phenylalaninol (1795-98-8,3182-95-4,5267-64-1,16088-07-6) → (2S,4R)-tert-butyl 2-((1-hydroxy-3-phenylpropan-2-yl)carbamoyl)-4-phenylpyrrolidine-1-carboxylate (1201986-84-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 18 - 25 ℃; for 16h;

upstream raw materials:

3-hydroxy-3,4-dihydrobenzotriazine-4-one

(2S,4R)-1-(tert-butoxycarbonyl)-4-phenyl-2-pyrrolidinecarboxylic acid

Downstream raw materials:

(2S,4R)-tert-butyl-4-phenyl-2-((R)-3-phenylpyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate

(2S,4R)-tert-butyl 2-((1-hydroxy-3-phenylpropan-2-yl)carbamoyl)-4-phenylpyrrolidine-1-carboxylate

(2S,4R)-tert-butyl 2-(4-benzyl-4,5-dihydrooxazol-2-yl)-4-phenylpyrrolidine-1-carboxylate

(2S,4R)-tert-butyl 2-(4-benzyloxazol-2-yl)-4-phenylpyrrolidine-1-carboxylate

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