2',3'-dihydro-5'-oxo-6'-(2(E)-phenylethenyl)spiro<1,3-dioxolane-2,1'(5'H)-indolizine>

Base Information

Chemical Name:2',3'-dihydro-5'-oxo-6'-(2(E)-phenylethenyl)spiro<1,3-dioxolane-2,1'(5'H)-indolizine>
CAS No.:92958-00-4
Molecular Formula:C₁₈H₁₇NO₃
Molecular Weight:295.338
Hs Code.:

Synonyms:2',3'-dihydro-5'-oxo-6'-(2(E)-phenylethenyl)spiro<1,3-dioxolane-2,1'(5'H)-indolizine>

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Chemical Property of 2',3'-dihydro-5'-oxo-6'-(2(E)-phenylethenyl)spiro<1,3-dioxolane-2,1'(5'H)-indolizine>

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Technology Process of 2',3'-dihydro-5'-oxo-6'-(2(E)-phenylethenyl)spiro<1,3-dioxolane-2,1'(5'H)-indolizine>

There total 8 articles about 2',3'-dihydro-5'-oxo-6'-(2(E)-phenylethenyl)spiro<1,3-dioxolane-2,1'(5'H)-indolizine> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88761-52-8
2',3'-dihydro-5'-oxo-6'-(2(E)-phenylethenyl)-7'-(trimethylsilyl)spiro<1,3-dioxolane-2,1'(5'H)-indolizine>

: 92958-00-4
2',3'-dihydro-5'-oxo-6'-(2(E)-phenylethenyl)spiro<1,3-dioxolane-2,1'(5'H)-indolizine>

Guidance literature:: With tetramethylammonium fluoride; In dimethyl sulfoxide; at 60 - 65 ℃; for 2h;
DOI:10.1021/jo00199a009

Reference yield:

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 92958-00-4
2',3'-dihydro-5'-oxo-6'-(2(E)-phenylethenyl)spiro<1,3-dioxolane-2,1'(5'H)-indolizine>

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / triphenylphosphine, triethylamine / PdCl₂(PhCN)2, CuI / Heating

2: tetramethylammoniumfluoride trihydrate / dimethylsulfoxide / 2 h / 60 - 65 °C

With tetramethylammonium fluoride; triethylamine; triphenylphosphine; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; In dimethyl sulfoxide;
DOI:10.1021/jo00199a009

Reference yield:

: 2-ethynyl-1,3-dioxolane-2-propanoic acid

: 92958-00-4
2',3'-dihydro-5'-oxo-6'-(2(E)-phenylethenyl)spiro<1,3-dioxolane-2,1'(5'H)-indolizine>

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / oxalyl chloride, DMF / benzene / 2 h / 25 - 35 °C

2: 84 percent / sodium azide / acetonitrile / 0.75 h / 65 - 75 °C

3: 68 percent / CpCo(CO)2 / 5.5 h / Heating; Irradiation

4: 86 percent / ICl / CCl₄; CH₂Cl₂ / 0 °C

5: 69 percent / triphenylphosphine, triethylamine / PdCl₂(PhCN)2, CuI / Heating

6: tetramethylammoniumfluoride trihydrate / dimethylsulfoxide / 2 h / 60 - 65 °C

With sodium azide; oxalyl dichloride; tetramethylammonium fluoride; Iodine monochloride; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; dicarbonylcyclopentadienylcobalt; In tetrachloromethane; dichloromethane; dimethyl sulfoxide; acetonitrile; benzene;
DOI:10.1021/jo00199a009