pyrimidine-5-carboxylic acid {1-[4-(4-bromo-2-chloro-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

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Chemical Name:pyrimidine-5-carboxylic acid {1-[4-(4-bromo-2-chloro-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide
CAS No.:1126631-61-5
Molecular Formula:C₂₂H₁₈BrClN₄O₃
Molecular Weight:501.767
Hs Code.:

Synonyms:pyrimidine-5-carboxylic acid {1-[4-(4-bromo-2-chloro-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

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Chemical Property of pyrimidine-5-carboxylic acid {1-[4-(4-bromo-2-chloro-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

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Technology Process of pyrimidine-5-carboxylic acid {1-[4-(4-bromo-2-chloro-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

There total 7 articles about pyrimidine-5-carboxylic acid {1-[4-(4-bromo-2-chloro-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 845829-96-1
1-[(pyrimidine-5-carbonyl)-amino]-cyclopropanecarboxylic acid

: 1039924-03-2
4-(4-bromo-2-chloro-phenoxy)-benzylamine

: 1126631-61-5
pyrimidine-5-carboxylic acid {1-[4-(4-bromo-2-chloro-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

Guidance literature:: 1-[(pyrimidine-5-carbonyl)-amino]-cyclopropanecarboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

4-(4-bromo-2-chloro-phenoxy)-benzylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 4595-61-3
pyrimidine-5-carboxylic acid

: 1126631-61-5
pyrimidine-5-carboxylic acid {1-[4-(4-bromo-2-chloro-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 0.5 h / 20 °C

2.1: sodium hydroxide; water / methanol / 1 h / 50 °C

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 20 °C

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 3964-56-5
4-bromo-2-chlorophenol

: 1126631-61-5
pyrimidine-5-carboxylic acid {1-[4-(4-bromo-2-chloro-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 120 °C

2.1: hydroxylamine / N,N-dimethyl-formamide; water / 1 h / 80 °C

3.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 20 °C

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h / 20 °C

4.2: 20 °C

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; hydroxylamine; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In water; dimethyl sulfoxide; N,N-dimethyl-formamide;