5-IODO-PYRIDINE-3-CARBALDEHYDE

Base Information

• Chemical Name: 5-IODO-PYRIDINE-3-CARBALDEHYDE
• CAS No.: 879326-76-8
• Molecular Formula: C₆H₄INO
• Molecular Weight: 233.008
• Mol file: 879326-76-8.mol

Synonyms:5-IODO-PYRIDINE-3-CARBALDEHYDE

Chemical Property of 5-IODO-PYRIDINE-3-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 148-149°C
• Refractive Index: 1.68
• Boiling Point: 300.847°C at 760 mmHg
• PKA: 1.41±0.20(Predicted)
• Flash Point: 135.748°C
• PSA: 29.96000
• Density: 2.002g/cm³
• LogP: 1.49870

Purity/Quality:

97% ^*data from raw suppliers

5-Iodo-pyridine-3-carbaldehyde Aldrich ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-IODO-PYRIDINE-3-CARBALDEHYDE

There total 2 articles about 5-IODO-PYRIDINE-3-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3,5-diiodopyridine (53710-18-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-iodonicotinaldehyde (879326-76-8)

Guidance literature:

3,5-diiodopyridine; With isopropylmagnesium chloride; lithium chloride; In tetrahydrofuran; at -78 ℃; for 3.5h; Schlenk technique; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 - 20 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.202101279

Reference yield:

3,5-dibromopyridine (625-92-3) → 5-iodonicotinaldehyde (879326-76-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(l) iodide; N,N`-dimethylethylenediamine; sodium iodide / 1,4-dioxane / 24 h / 120 °C / Schlenk technique

2.1: TurboGrignard / tetrahydrofuran / 3.5 h / -78 °C / Schlenk technique; Inert atmosphere

2.2: 12 h / -78 - 20 °C / Schlenk technique; Inert atmosphere

With copper(l) iodide; TurboGrignard; sodium iodide; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; 1.1: |Finkelstein Reaction;

DOI:10.1002/ejoc.202101280

Reference yield:

5-iodonicotinaldehyde (879326-76-8) → 3-(1-((tert-butyldiphenylsilyl)oxy)ethyl)-5-iodopyridine

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; diethyl ether / 1.17 h / -78 - 0 °C / Inert atmosphere

2: 1H-imidazole / dichloromethane / 22 °C

With 1H-imidazole; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1002/ejoc.202101280

upstream raw materials:

3,5-diiodopyridine

N,N-dimethyl-formamide

3,5-dibromopyridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 879326-76-8 5-IODO-PYRIDINE-3-CARBALDEHYDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send