N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-formyl-N-methylbenzamide

Base Information

• Chemical Name: N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-formyl-N-methylbenzamide
• CAS No.: 217973-35-8
• Molecular Formula: C₂₆H₃₃N₅O₄
• Molecular Weight: 479.579
• Mol file: 217973-35-8.mol

Synonyms:N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-formyl-N-methylbenzamide

Chemical Property of N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-formyl-N-methylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-formyl-N-methylbenzamide

There total 2 articles about N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-formyl-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-formyl benzoyl chloride (117886-88-1) + 6,7-Dimethoxy-N2-methyl-N2-(6-methylamino-hexyl)-quinazoline-2,4-diamine (217973-01-8) → N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-formyl-N-methylbenzamide (217973-35-8)

Guidance literature:

With triethylamine; In 1,4-dioxane; for 24h; Ambient temperature;

DOI:10.1021/jm9810654

Reference yield:

o-carboxybenzaldehyde (119-67-5) → N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-formyl-N-methylbenzamide (217973-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / SOCl₂ / benzene / 1 h / Heating

2: 87 percent / Et₃N / dioxane / 24 h / Ambient temperature

With thionyl chloride; triethylamine; In 1,4-dioxane; benzene;

DOI:10.1021/jm9810654

Reference yield: 79.0%

N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-formyl-N-methylbenzamide (217973-35-8) → N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-hydroxymethyl-N-methylbenzamide (788141-76-4)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 3h;

DOI:10.1021/jm9810654

upstream raw materials:

2-formyl benzoyl chloride

6,7-Dimethoxy-N²-methyl-N²-(6-methylamino-hexyl)-quinazoline-2,4-diamine

o-carboxybenzaldehyde

Downstream raw materials:

N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-hydroxymethyl-N-methylbenzamide