N,N'-bis[4-(methoxymethoxy)benzoyl]-2,6-bis[(6-aminopyrid-2-yl)ethynyl]pyridine

Base Information

Chemical Name:N,N'-bis[4-(methoxymethoxy)benzoyl]-2,6-bis[(6-aminopyrid-2-yl)ethynyl]pyridine
CAS No.:251640-60-5
Molecular Formula:C₃₇H₂₉N₅O₆
Molecular Weight:639.667
Hs Code.:

Synonyms:N,N'-bis[4-(methoxymethoxy)benzoyl]-2,6-bis[(6-aminopyrid-2-yl)ethynyl]pyridine

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Chemical Property of N,N'-bis[4-(methoxymethoxy)benzoyl]-2,6-bis[(6-aminopyrid-2-yl)ethynyl]pyridine

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Technology Process of N,N'-bis[4-(methoxymethoxy)benzoyl]-2,6-bis[(6-aminopyrid-2-yl)ethynyl]pyridine

There total 7 articles about N,N'-bis[4-(methoxymethoxy)benzoyl]-2,6-bis[(6-aminopyrid-2-yl)ethynyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 626-05-1
2,6-Dibromopyridine

: 251640-59-2
N-(6-ethynyl-2-pyridyl)-4-(methoxymethoxy)benzamide

: 251640-60-5
N,N'-bis[4-(methoxymethoxy)benzoyl]-2,6-bis[(6-aminopyrid-2-yl)ethynyl]pyridine

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 60 ℃; for 4h;
DOI:10.1021/jo9911138

Reference yield:

: 94-26-8
4-hydroxybenzoic acid, butyl ester

: 251640-60-5
N,N'-bis[4-(methoxymethoxy)benzoyl]-2,6-bis[(6-aminopyrid-2-yl)ethynyl]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / NaH / tetrahydrofuran / 12 h / 20 °C

2: 87 percent / KOH / ethanol / 3 h / 20 °C

3: 52 percent / Ph₃P; BrCCl₃ / tetrahydrofuran / 1.5 h / Heating

4: 96 percent / Et₂NH / (Ph₃P)2PdCl₂; CuI / 4 h / 20 °C

5: 73 percent / NaH / toluene / 0.67 h / 120 °C

6: 78 percent / Et₃N / (Ph₃P)2PdCl₂; CuI / 4 h / 60 °C

With potassium hydroxide; Bromotrichloromethane; sodium hydride; diethylamine; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; ethanol; toluene; 1: Etherification / 2: Hydrolysis / 3: Acylation / 4: Sonogashira reaction / 5: Elimination / 6: Sonogashira reaction;
DOI:10.1021/jo9911138

Reference yield:

: 19798-81-3,1184170-10-2
2-Amino-6-bromopyridine

: 251640-60-5
N,N'-bis[4-(methoxymethoxy)benzoyl]-2,6-bis[(6-aminopyrid-2-yl)ethynyl]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 52 percent / Ph₃P; BrCCl₃ / tetrahydrofuran / 1.5 h / Heating

2: 96 percent / Et₂NH / (Ph₃P)2PdCl₂; CuI / 4 h / 20 °C

3: 73 percent / NaH / toluene / 0.67 h / 120 °C

4: 78 percent / Et₃N / (Ph₃P)2PdCl₂; CuI / 4 h / 60 °C

With Bromotrichloromethane; sodium hydride; diethylamine; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; toluene; 1: Acylation / 2: Sonogashira reaction / 3: Elimination / 4: Sonogashira reaction;
DOI:10.1021/jo9911138