tert-butyl 4-(2-amino-5-chlorobenzoyl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(2-amino-5-chlorobenzoyl)piperazine-1-carboxylate
• CAS No.: 1235987-64-0
• Molecular Formula: C₁₆H₂₂ClN₃O₃
• Molecular Weight: 339.822
• Mol file: 1235987-64-0.mol

Synonyms:tert-butyl 4-(2-amino-5-chlorobenzoyl)piperazine-1-carboxylate

Chemical Property of tert-butyl 4-(2-amino-5-chlorobenzoyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl 4-(2-amino-5-chlorobenzoyl)piperazine-1-carboxylate

There total 2 articles about tert-butyl 4-(2-amino-5-chlorobenzoyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloroanthranilic acid (635-21-2) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(2-amino-5-chlorobenzoyl)piperazine-1-carboxylate (1235987-64-0)

Guidance literature:

In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

5-Chloroisatoic anhydride (4743-17-3) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(2-amino-5-chlorobenzoyl)piperazine-1-carboxylate (1235987-64-0)

Guidance literature:

In 1,4-dioxane; for 4h; Reflux;

DOI:10.1016/j.bmcl.2010.04.037

Reference yield:

tert-butyl 4-(2-amino-5-chlorobenzoyl)piperazine-1-carboxylate (1235987-64-0) → (2-amino-5-chlorophenyl)(piperazin-1-yl)methanone

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃; for 8h;

DOI:10.1021/acs.jmedchem.8b00704

upstream raw materials:

5-Chloroisatoic anhydride

1-t-Butoxycarbonylpiperazine

5-chloroanthranilic acid

Downstream raw materials:

C₂₆H₂₈ClN₃O₅

C₂₇H₃₀ClN₃O₃