1,1-dimethylethyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]carbamate

Base Information

• Chemical Name: 1,1-dimethylethyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]carbamate
• CAS No.: 1044851-42-4
• Molecular Formula: C₂₂H₂₄N₂O₄
• Molecular Weight: 380.444
• Mol file: 1044851-42-4.mol

Synonyms:1,1-dimethylethyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]carbamate

Chemical Property of 1,1-dimethylethyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]carbamate

There total 5 articles about 1,1-dimethylethyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

phthalimide (136918-14-4,85-41-6) + (RS)-2-<(tert-Butoxycarbonyl)amino>-1-benzylethanol (162541-45-9) → 1,1-dimethylethyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]carbamate (1044851-42-4)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 1.08333h;

Reference yield:

phthalimide (136918-14-4,85-41-6) + di-tert-butyl dicarbonate (24424-99-5) + (RS)-2-<(tert-Butoxycarbonyl)amino>-1-benzylethanol (162541-45-9) → 1,1-dimethylethyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]carbamate (1044851-42-4)

Guidance literature:

phthalimide; (RS)-2-<(tert-Butoxycarbonyl)amino>-1-benzylethanol; With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃; for 1h;

di-tert-butyl dicarbonate; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 1,1-dimethylethyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]carbamate (1044851-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.17 h / 20 °C

1.2: 2 h / 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 1 h / 20 °C

2.2: 2 h / 20 °C

With triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene;

upstream raw materials:

phthalimide

(RS)-2-<(tert-Butoxycarbonyl)amino>-1-benzylethanol

di-tert-butyl dicarbonate

1-amino-3-phenylpropan-2-ol hydrochloride

Downstream raw materials:

tert-butyl (2-amino-3-phenylpropyl)carbamate

C₃₀H₃₄N₂O₈

C₂₄H₂₂N₂O₅

C₂₆H₂₆N₂O₅