tert-Butyl-[(8R,9R)-8-(4-methoxy-benzyloxy)-1,4,6-trioxa-spiro[4.5]dec-9-yloxy]-dimethyl-silane

Base Information

Chemical Name:tert-Butyl-[(8R,9R)-8-(4-methoxy-benzyloxy)-1,4,6-trioxa-spiro[4.5]dec-9-yloxy]-dimethyl-silane
CAS No.:273918-27-7
Molecular Formula:C₂₁H₃₄O₆Si
Molecular Weight:410.583
Hs Code.:

Synonyms:tert-Butyl-[(8R,9R)-8-(4-methoxy-benzyloxy)-1,4,6-trioxa-spiro[4.5]dec-9-yloxy]-dimethyl-silane

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Chemical Property of tert-Butyl-[(8R,9R)-8-(4-methoxy-benzyloxy)-1,4,6-trioxa-spiro[4.5]dec-9-yloxy]-dimethyl-silane

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Technology Process of tert-Butyl-[(8R,9R)-8-(4-methoxy-benzyloxy)-1,4,6-trioxa-spiro[4.5]dec-9-yloxy]-dimethyl-silane

There total 10 articles about tert-Butyl-[(8R,9R)-8-(4-methoxy-benzyloxy)-1,4,6-trioxa-spiro[4.5]dec-9-yloxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 94-33-7
C₉H₁₀O₃

: Acetic acid (3R,4S,5R)-4-acetoxy-5-(4-methoxy-benzyloxy)-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yl ester

: 273918-27-7
tert-Butyl-[(8R,9R)-8-(4-methoxy-benzyloxy)-1,4,6-trioxa-spiro[4.5]dec-9-yloxy]-dimethyl-silane

Guidance literature:: Multistep reaction;
DOI:10.1002/1521-3765(20000901)6:17<3166::AID-CHEM3166>3.0.CO;2-Z

Reference yield:

: 886840-93-3
C₂₇H₄₀O₇SeSi

: 273918-27-7
tert-Butyl-[(8R,9R)-8-(4-methoxy-benzyloxy)-1,4,6-trioxa-spiro[4.5]dec-9-yloxy]-dimethyl-silane

Guidance literature:: With vinyl acetate; diisopropylamine; In toluene; at 140 ℃; for 12h;
DOI:10.1002/1521-3765(20000901)6:17<3166::AID-CHEM3166>3.0.CO;2-Z

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 273918-27-7
tert-Butyl-[(8R,9R)-8-(4-methoxy-benzyloxy)-1,4,6-trioxa-spiro[4.5]dec-9-yloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -78 °C

2: 100 percent / DAST / CH₂Cl₂ / 0.5 h / 0 °C

3: 94 percent / SnCl₂; molecular sieves 4 Angstroem / diethyl ether / 3 h / 0 - 25 °C

4: 95 percent / NaOMe; MeOH / 3 h / 25 °C

5: aq. NaIO₄ / methanol; CH₂Cl₂ / 1 h / 25 °C

6: 49 mg / iPr₂NH; vinyl acetate / toluene / 12 h / 140 °C

With 2,6-dimethylpyridine; methanol; sodium periodate; vinyl acetate; 4 A molecular sieve; sodium methylate; diisopropylamine; 4,4'-diaminostilbene-2,2'-disulfonic acid; tin(ll) chloride; In methanol; diethyl ether; dichloromethane; toluene; 1: Etherification / 2: Rearrangement / 3: Glycosidation / 4: Debenzoylation / 5: Oxidation / 6: Cyclization;
DOI:10.1002/1521-3765(20000901)6:17<3166::AID-CHEM3166>3.0.CO;2-Z