N-Methyl(1-phenyl-3-methylpyrazol-5-yl)-2-carbomethoxybenzamide

Base Information

• Chemical Name: N-Methyl(1-phenyl-3-methylpyrazol-5-yl)-2-carbomethoxybenzamide
• CAS No.: 83451-33-6
• Molecular Formula: C₂₀H₁₉N₃O₃
• Molecular Weight: 349.389
• Mol file: 83451-33-6.mol

Synonyms:N-Methyl(1-phenyl-3-methylpyrazol-5-yl)-2-carbomethoxybenzamide

Chemical Property of N-Methyl(1-phenyl-3-methylpyrazol-5-yl)-2-carbomethoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-Methyl(1-phenyl-3-methylpyrazol-5-yl)-2-carbomethoxybenzamide

There total 1 articles about N-Methyl(1-phenyl-3-methylpyrazol-5-yl)-2-carbomethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-Methyl-5-methylamino-1-phenyl-1H-pyrazole (57047-10-6) + phthalic monoacid monomethyl ester chloride (4397-55-1) → N-Methyl(1-phenyl-3-methylpyrazol-5-yl)-2-carbomethoxybenzamide (83451-33-6)

Guidance literature:

With triethylamine; In chloroform; for 3h; Heating;

Reference yield: 85.0%

N-Methyl(1-phenyl-3-methylpyrazol-5-yl)-2-carbomethoxybenzamide (83451-33-6) → N-Methyl-(1-phenyl-3-methylpyrazol-5-yl)-2-carboxybenzamide (83451-35-8)

Guidance literature:

With sodium hydroxide; In ethanol; Heating;

Reference yield:

N-Methyl(1-phenyl-3-methylpyrazol-5-yl)-2-carbomethoxybenzamide (83451-33-6) → 3,10-Dimethyl-1-phenyl-1,10-dihydro-1,2,10-triaza-benzo[f]azulene-4,9-dione (83451-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / 4percent aq. NaOH / ethanol / Heating

2: 28 percent / POCl₃, H₂O / 5 h / Heating

With sodium hydroxide; water; trichlorophosphate; In ethanol;

upstream raw materials:

3-Methyl-5-methylamino-1-phenyl-1H-pyrazole

phthalic monoacid monomethyl ester chloride

Downstream raw materials:

N-Methyl-(1-phenyl-3-methylpyrazol-5-yl)-2-carboxybenzamide

3,10-Dimethyl-1-phenyl-1,10-dihydro-1,2,10-triaza-benzo[f]azulene-4,9-dione