(E)-2,5-Dibutoxy-4-(2,5-dimethoxy-4-(pyrrolidin-1-yl)styryl)bromobenzene

Base Information

Chemical Name:(E)-2,5-Dibutoxy-4-(2,5-dimethoxy-4-(pyrrolidin-1-yl)styryl)bromobenzene
CAS No.:1350616-01-1
Molecular Formula:C₂₈H₃₈BrNO₄
Molecular Weight:532.518
Hs Code.:

Synonyms:(E)-2,5-Dibutoxy-4-(2,5-dimethoxy-4-(pyrrolidin-1-yl)styryl)bromobenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2,5-Dibutoxy-4-(2,5-dimethoxy-4-(pyrrolidin-1-yl)styryl)bromobenzene

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Technology Process of (E)-2,5-Dibutoxy-4-(2,5-dimethoxy-4-(pyrrolidin-1-yl)styryl)bromobenzene

There total 3 articles about (E)-2,5-Dibutoxy-4-(2,5-dimethoxy-4-(pyrrolidin-1-yl)styryl)bromobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 960081-01-0
diethyl (2,5-bisbutoxy-4-bromobenzyl)phosphonate

: 692775-87-4
2,5-dimethoxy-4-(pyrrolidin-1-yl)benzaldehyde

: 1350616-01-1
(E)-2,5-Dibutoxy-4-(2,5-dimethoxy-4-(pyrrolidin-1-yl)styryl)bromobenzene

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo202015m

Reference yield:

: 1350615-95-0
1-(2,5-dimethoxyphenyl)pyrrolidine

: 1350616-01-1
(E)-2,5-Dibutoxy-4-(2,5-dimethoxy-4-(pyrrolidin-1-yl)styryl)bromobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 95 °C / Cooling with ice; Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With potassium tert-butylate; trichlorophosphate; In tetrahydrofuran; 2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jo202015m

Reference yield:

: 102-56-7,102526-87-4
2,5-dimethoxyaniline

: 1350616-01-1
(E)-2,5-Dibutoxy-4-(2,5-dimethoxy-4-(pyrrolidin-1-yl)styryl)bromobenzene

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide / 48 h / 120 °C

2: trichlorophosphate / 95 °C / Cooling with ice; Inert atmosphere

3: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With potassium tert-butylate; potassium carbonate; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; 3: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jo202015m