methyl 5-(chlorodifluoromethyl)-3-(3-fluorophenyl)-4-isoxazolecarboxylate

Base Information

• Chemical Name: methyl 5-(chlorodifluoromethyl)-3-(3-fluorophenyl)-4-isoxazolecarboxylate
• CAS No.: 849440-94-4
• Molecular Formula: C₁₂H₇ClF₃NO₃
• Molecular Weight: 305.641
• Mol file: 849440-94-4.mol

Synonyms:methyl 5-(chlorodifluoromethyl)-3-(3-fluorophenyl)-4-isoxazolecarboxylate

Chemical Property of methyl 5-(chlorodifluoromethyl)-3-(3-fluorophenyl)-4-isoxazolecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 5-(chlorodifluoromethyl)-3-(3-fluorophenyl)-4-isoxazolecarboxylate

There total 2 articles about methyl 5-(chlorodifluoromethyl)-3-(3-fluorophenyl)-4-isoxazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

methyl 4,4-difluoro-4-chloro-2-butynoate (143706-83-6) + N-hydroxy-3-fluoro-benzenecarboximidoyl chloride (58606-42-1) → methyl 5-(chlorodifluoromethyl)-3-(3-fluorophenyl)-4-isoxazolecarboxylate (849440-94-4)

Guidance literature:

With sodium hydroxide; In dichloromethane; at -5 - 5 ℃; for 0.25h;

DOI:10.1021/jf00049a040

Reference yield:

3-fluoro-benzaldehyde seqtrans-oxime (458-02-6,154238-36-5) → methyl 5-(chlorodifluoromethyl)-3-(3-fluorophenyl)-4-isoxazolecarboxylate (849440-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-chlorosuccinimide / dimethylformamide / Ambient temperature

2: 67 percent / 5percent aq. NaOH / CH₂Cl₂ / 0.25 h / -5 - 5 °C

With sodium hydroxide; N-chloro-succinimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jf00049a040

Reference yield: 77.0%

methyl 5-(chlorodifluoromethyl)-3-(3-fluorophenyl)-4-isoxazolecarboxylate (849440-94-4) → methyl 5-(chlorodifluoromethyl)-3-(3-fluoro-2-nitrophenyl)-4-isoxazolecarboxylate

Guidance literature:

With nitric acid; for 1h; Ambient temperature;

DOI:10.1021/jf00049a040

upstream raw materials:

methyl 4,4-difluoro-4-chloro-2-butynoate

N-hydroxy-3-fluoro-benzenecarboximidoyl chloride

3-fluoro-benzaldehyde seqtrans-oxime