6(S)-(1(S)-methyl-2-cyanoethyl)-4(S)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2,2,5(S)-trimethyl-1,3-dioxane

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Chemical Name:6(S)-(1(S)-methyl-2-cyanoethyl)-4(S)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2,2,5(S)-trimethyl-1,3-dioxane
CAS No.:112452-64-9
Molecular Formula:C₃₀H₄₃NO₃Si
Molecular Weight:493.762
Hs Code.:

Synonyms:6(S)-(1(S)-methyl-2-cyanoethyl)-4(S)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2,2,5(S)-trimethyl-1,3-dioxane

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Chemical Property of 6(S)-(1(S)-methyl-2-cyanoethyl)-4(S)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2,2,5(S)-trimethyl-1,3-dioxane

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Technology Process of 6(S)-(1(S)-methyl-2-cyanoethyl)-4(S)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2,2,5(S)-trimethyl-1,3-dioxane

There total 14 articles about 6(S)-(1(S)-methyl-2-cyanoethyl)-4(S)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2,2,5(S)-trimethyl-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115047-25-1,122292-23-3,126720-99-8
(E)-(2S,3S,4S,5S,6S)-1-(tert-Butyl-diphenyl-silanyloxy)-2,4,6,9-tetramethyl-dec-7-ene-3,5-diol

: 112452-64-9
6(S)-(1(S)-methyl-2-cyanoethyl)-4(S)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2,2,5(S)-trimethyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 4 steps

1: 93 mg / p-TsOH / 4 h / 25 °C

3: pyridine / 18 h / -6 °C

4: 14 mg / dimethylsulfoxide / 24 h / 80 °C

With pyridine; toluene-4-sulfonic acid; In dimethyl sulfoxide;
DOI:10.1021/ja00224a032

Reference yield:

: 110455-56-6
3(S)-(1(S),4-dimethyl-2(E)-pentenyl)-4(S)-methyl-5(R)-<1(S)-methyl-2<(tert-butyldiphenylsilyl)oxy>ethyl>dihydro-2(3H)-furanone

: 112452-64-9
6(S)-(1(S)-methyl-2-cyanoethyl)-4(S)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2,2,5(S)-trimethyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 7 steps

1: diethyl ether / 15 h / -18 °C

2: H₂O₂, HOAc / tetrahydrofuran / 0 deg C, 30 min, 25 deg C, 16 h

3: 1.)triethylamine, 4-(dimethylamino)pyridine, acetic anhydride, 2.) diisobutylaluminum hydride / 1.) CH₂Cl₂, 0 deg C, 30 min, 25 deg C, 1 h, reflux, 6 h, 2.) CH₂Sl₂, -78 deg C, 2 h

4: 93 mg / p-TsOH / 4 h / 25 °C

6: pyridine / 18 h / -6 °C

7: 14 mg / dimethylsulfoxide / 24 h / 80 °C

With pyridine; dmap; dihydrogen peroxide; acetic anhydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1021/ja00224a032