(E)-4,4-bis(phenylsulfonyl)-1-phenyl-7-methyl-8-trimethylsilyl-6-octen-1-yne

Base Information

Chemical Name:(E)-4,4-bis(phenylsulfonyl)-1-phenyl-7-methyl-8-trimethylsilyl-6-octen-1-yne
CAS No.:259879-51-1
Molecular Formula:C₃₀H₃₄O₄S₂Si
Molecular Weight:550.815
Hs Code.:

Synonyms:(E)-4,4-bis(phenylsulfonyl)-1-phenyl-7-methyl-8-trimethylsilyl-6-octen-1-yne

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-4,4-bis(phenylsulfonyl)-1-phenyl-7-methyl-8-trimethylsilyl-6-octen-1-yne

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Technology Process of (E)-4,4-bis(phenylsulfonyl)-1-phenyl-7-methyl-8-trimethylsilyl-6-octen-1-yne

There total 5 articles about (E)-4,4-bis(phenylsulfonyl)-1-phenyl-7-methyl-8-trimethylsilyl-6-octen-1-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 259879-66-8
(E)-5,5-bis(phenylsulfonyl)-2-methyl-1-trimethylsilyl-2-pentene

: 1794-48-5
1-bromo-3-phenylprop-2-yne

: 259879-51-1
(E)-4,4-bis(phenylsulfonyl)-1-phenyl-7-methyl-8-trimethylsilyl-6-octen-1-yne

Guidance literature:: (E)-5,5-bis(phenylsulfonyl)-2-methyl-1-trimethylsilyl-2-pentene; With sodium hydride; In N,N-dimethyl-formamide; at 23 ℃; for 0.5h;

1-bromo-3-phenylprop-2-yne; In N,N-dimethyl-formamide; at 23 ℃; for 17h; Further stages.;
DOI:10.1021/jo025812n

Reference yield:

: 259879-65-7
5,5-bis(phenylsulfonyl)-2-methyl-1-trifluoroacetyloxy-2-pentene

: 259879-51-1
(E)-4,4-bis(phenylsulfonyl)-1-phenyl-7-methyl-8-trimethylsilyl-6-octen-1-yne

Guidance literature:: Multi-step reaction with 2 steps

1.1: 76 percent / Pd₂(dba)3*dba / tetrahydrofuran / 12 h / 23 °C

2.1: NaH / dimethylformamide / 0.5 h / 23 °C

2.2: 68 percent / dimethylformamide / 17 h / 23 °C

With Pd₂(dba)4; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo025812n

Reference yield:

: 3406-02-8
bis(phenylsulfonyl)methane

: 259879-51-1
(E)-4,4-bis(phenylsulfonyl)-1-phenyl-7-methyl-8-trimethylsilyl-6-octen-1-yne

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / Pd₂(dba)3*(dba); dppe / tetrahydrofuran / 17 h / 23 °C

2.1: 83 percent / DMAP; i-PrEt₂N / CH₂Cl₂ / 2.5 h / 23 °C

3.1: 76 percent / Pd₂(dba)3*dba / tetrahydrofuran / 12 h / 23 °C

4.1: NaH / dimethylformamide / 0.5 h / 23 °C

4.2: 68 percent / dimethylformamide / 17 h / 23 °C

With dmap; Pd₂(dba)4; N,N-diethyl-N-isopropylamine; sodium hydride; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo025812n