6-[(2-nitrophenyl)sulfonyl]-6,7,8,13-tetrahydro-5H-azepino[2,3-b:4,5-b']diindole

Base Information

Chemical Name:6-[(2-nitrophenyl)sulfonyl]-6,7,8,13-tetrahydro-5H-azepino[2,3-b:4,5-b']diindole
CAS No.:1610967-43-5
Molecular Formula:C₂₄H₁₈N₄O₄S
Molecular Weight:458.497
Hs Code.:

Synonyms:6-[(2-nitrophenyl)sulfonyl]-6,7,8,13-tetrahydro-5H-azepino[2,3-b:4,5-b']diindole

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Chemical Property of 6-[(2-nitrophenyl)sulfonyl]-6,7,8,13-tetrahydro-5H-azepino[2,3-b:4,5-b']diindole

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Technology Process of 6-[(2-nitrophenyl)sulfonyl]-6,7,8,13-tetrahydro-5H-azepino[2,3-b:4,5-b']diindole

There total 3 articles about 6-[(2-nitrophenyl)sulfonyl]-6,7,8,13-tetrahydro-5H-azepino[2,3-b:4,5-b']diindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1610967-40-2
N-[2-(1H-indol-3-yl)ethyl]-N-[(2-azidophenyl)ethynyl]-2-nitrobenzenesulfonamide

: 1610967-43-5
6-[(2-nitrophenyl)sulfonyl]-6,7,8,13-tetrahydro-5H-azepino[2,3-b:4,5-b']diindole

Guidance literature:: With C₂₁H₁₂AuClF₉P*CF₃O₃S^(1-)*Ag⁽¹⁺⁾; In nitromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ol5012604

Reference yield:

: 210880-58-3
[(2-azidophenyl)ethynyl]trimethylsilane

: 1610967-43-5
6-[(2-nitrophenyl)sulfonyl]-6,7,8,13-tetrahydro-5H-azepino[2,3-b:4,5-b']diindole

Guidance literature:: Multi-step reaction with 3 steps

1.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: copper(l) iodide; potassium phosphate / tetrahydrofuran / 3 h / 50 °C

3.1: C₂₁H₁₂AuClF₉P*CF₃O₃S^(1-)*Ag⁽¹⁺⁾ / nitromethane / 0.5 h / 20 °C

With potassium phosphate; copper(l) iodide; trimethylsilyl trifluoromethanesulfonate; C₂₁H₁₂AuClF₉P*CF₃O₃S^(1-)*Ag⁽¹⁺⁾; In tetrahydrofuran; nitromethane; acetonitrile;
DOI:10.1021/ol5012604

Reference yield:

: 1610967-50-4
1-[(2-azidophenyl)ethynyl]-5-nitro-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

: 1610967-43-5
6-[(2-nitrophenyl)sulfonyl]-6,7,8,13-tetrahydro-5H-azepino[2,3-b:4,5-b']diindole

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; potassium phosphate / tetrahydrofuran / 3 h / 50 °C

2: C₂₁H₁₂AuClF₉P*CF₃O₃S^(1-)*Ag⁽¹⁺⁾ / nitromethane / 0.5 h / 20 °C

With potassium phosphate; copper(l) iodide; C₂₁H₁₂AuClF₉P*CF₃O₃S^(1-)*Ag⁽¹⁺⁾; In tetrahydrofuran; nitromethane;
DOI:10.1021/ol5012604