ethyl 5-(acetylamino)-2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate

Base Information

Chemical Name:ethyl 5-(acetylamino)-2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate
CAS No.:151323-46-5
Molecular Formula:C₄₆H₄₃N₇O₃
Molecular Weight:741.893
Hs Code.:

ethyl 5-(acetylamino)-2-<N-propyl-N-<<2'-<2-(triphenylmethyl)-2H-tetrazol-5-yl>biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate

Synonyms:ethyl 5-(acetylamino)-2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate

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Chemical Property of ethyl 5-(acetylamino)-2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate

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Technology Process of ethyl 5-(acetylamino)-2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate

There total 8 articles about ethyl 5-(acetylamino)-2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 609-71-2
2-hydroxy-3-carboxypyridine

: 151323-46-5
ethyl 5-(acetylamino)-2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / nitric acid, sulfuric acid / 1.) RT, 16 h, 2.) from 50 deg C to 70 deg C, 1.5 h

2: thionyl chloride / dimethylformamide / 2 h / Heating

3: dimethylformamide

4: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

5: 82 percent / H₂ / 10percent Pd/C / ethyl acetate / 10 h / 760 Torr

6: Et₃N / CHCl₃

With thionyl chloride; sulfuric acid; hydrogen; nitric acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00070a012

Reference yield:

: 6854-07-5
2-hydroxy-5-nitropyridine-3-carboxylic acid

: 151323-46-5
ethyl 5-(acetylamino)-2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / dimethylformamide / 2 h / Heating

2: dimethylformamide

3: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

4: 82 percent / H₂ / 10percent Pd/C / ethyl acetate / 10 h / 760 Torr

5: Et₃N / CHCl₃

With thionyl chloride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00070a012

Reference yield:

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 151323-46-5
ethyl 5-(acetylamino)-2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 2 h / Ambient temperature

2: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

3: 82 percent / H₂ / 10percent Pd/C / ethyl acetate / 10 h / 760 Torr

4: Et₃N / CHCl₃

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; chloroform; ethyl acetate;
DOI:10.1021/jm00070a012