3-<(4'-hydroxymethyl)phenyl>-3-trimethylsilylpropanoic acid

Base Information Edit

Chemical Name:3-<(4'-hydroxymethyl)phenyl>-3-trimethylsilylpropanoic acid
CAS No.:114671-15-7
Molecular Formula:C₁₃H₂₀O₃Si
Molecular Weight:252.386
Hs Code.:
Mol file:114671-15-7.mol

Synonyms:3-<(4'-hydroxymethyl)phenyl>-3-trimethylsilylpropanoic acid

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Chemical Property of 3-<(4'-hydroxymethyl)phenyl>-3-trimethylsilylpropanoic acid Edit

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Technology Process of 3-<(4'-hydroxymethyl)phenyl>-3-trimethylsilylpropanoic acid

There total 6 articles about 3-<(4'-hydroxymethyl)phenyl>-3-trimethylsilylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 114671-14-6
methyl 3-<(4'-acetoxymethyl)phenyl>-3-trimethylsilylpropanoate

: 114671-15-7
3-<(4'-hydroxymethyl)phenyl>-3-trimethylsilylpropanoic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; for 24h;
DOI:10.1016/S0040-4020(01)89012-8

Reference yield:

: 139932-41-5
methyl 3-<(4'-bromomethyl)phenyl>-3-trimethylsilylpropanoate

: 114671-15-7
3-<(4'-hydroxymethyl)phenyl>-3-trimethylsilylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / 18-crown-6 / acetonitrile / 0.5 h / Heating

2: 55 percent / aq. NaOH / dioxane / 24 h

With sodium hydroxide; 18-crown-6 ether; In 1,4-dioxane; acetonitrile;
DOI:10.1016/S0040-4020(01)89012-8

Reference yield:

: 1866-39-3,940-61-4
trans-p-methylcinnamic acid

: 114671-15-7
3-<(4'-hydroxymethyl)phenyl>-3-trimethylsilylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂

2: Mg, N,N-dimethyl ethylene urea (DMEU) / tetrahydrofuran / 55 - 60 °C

3: N-bromosuccinimide / CCl₄ / Irradiation

4: 18-Crown-6 / acetonitrile

5: NaOH aq / dioxane

With N,N-dimethyl ethylene urea; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; 18-crown-6 ether; magnesium; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; acetonitrile;
DOI:10.1016/S0040-4039(01)83873-9