4-(2-Cyano-phenyl)-2-hydroxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(2-ethylsulfanyl-ethyl) ester

Base Information

Chemical Name:4-(2-Cyano-phenyl)-2-hydroxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(2-ethylsulfanyl-ethyl) ester
CAS No.:74655-45-1
Molecular Formula:C₂₂H₂₆N₂O₅S
Molecular Weight:430.525
Hs Code.:

Synonyms:4-(2-Cyano-phenyl)-2-hydroxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(2-ethylsulfanyl-ethyl) ester

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Chemical Property of 4-(2-Cyano-phenyl)-2-hydroxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(2-ethylsulfanyl-ethyl) ester

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Technology Process of 4-(2-Cyano-phenyl)-2-hydroxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(2-ethylsulfanyl-ethyl) ester

There total 5 articles about 4-(2-Cyano-phenyl)-2-hydroxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(2-ethylsulfanyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.4%

: 74655-39-3
4-(2-Cyano-phenyl)-2-formyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(2-ethylsulfanyl-ethyl) ester

: 74655-45-1
4-(2-Cyano-phenyl)-2-hydroxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(2-ethylsulfanyl-ethyl) ester

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 - 5 ℃; for 1h;
DOI:10.1248/cpb.40.912

Reference yield:

: 7468-67-9
o-formylbenzonitrile

: 74655-45-1
4-(2-Cyano-phenyl)-2-hydroxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(2-ethylsulfanyl-ethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine / benzene / 3 h / Heating

2: 3 h / 110 °C

3: 79.4 percent / aq. HCl / acetone / 1.5 h / Ambient temperature

4: 91.4 percent / NaBH₄ / ethanol / 1 h / 0 - 5 °C

With piperidine; hydrogenchloride; sodium tetrahydroborate; In ethanol; acetone; benzene;
DOI:10.1248/cpb.40.912

Reference yield:

: 75090-79-8
acetoacetic acid-(2-ethylthioethyl)-ester

: 74655-45-1
4-(2-Cyano-phenyl)-2-hydroxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(2-ethylsulfanyl-ethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine / benzene / 3 h / Heating

2: 3 h / 110 °C

3: 79.4 percent / aq. HCl / acetone / 1.5 h / Ambient temperature

4: 91.4 percent / NaBH₄ / ethanol / 1 h / 0 - 5 °C

With piperidine; hydrogenchloride; sodium tetrahydroborate; In ethanol; acetone; benzene;
DOI:10.1248/cpb.40.912