2-(2-Methoxyethoxy)ethanethiol

Base Information

• Chemical Name: 2-(2-Methoxyethoxy)ethanethiol
• CAS No.: 88778-21-6
• Molecular Formula: C5H12 O2 S
• Molecular Weight: 136.215
• Hs Code.: 2930909090
• European Community (EC) Number: 854-974-4
• DSSTox Substance ID: DTXSID30464636
• Nikkaji Number: J1.737.435D
• Wikidata: Q82290039
• Mol file: 88778-21-6.mol

Synonyms:2-(2-methoxyethoxy)ethanethiol;88778-21-6;M-PEG2-SH;2-(2-methoxyethoxy)ethane-1-thiol;Ethanethiol, 2-(2-methoxyethoxy)-;SCHEMBL444766;m-PEG-thiol, MW 1,000;m-PEG-thiol, MW 2,000;m-PEG-thiol, MW 5,000;2-(2-Methoxyethoxyl)ethanethiol;DTXSID30464636;m-PEG-thiol, MW 10,000;m-PEG-thiol, MW 20,000;m-PEG-thiol, MW 30,000;CDBORKXXLPAUKJ-UHFFFAOYSA-N;MFCD06252462;AKOS013153637;AKOS015964436;AT10124;BP-23720;BP-23721;BP-23722;BP-23723;BP-28743;BP-28744;2-(2-METHOXYETHOXY)ETHANETHIOL, 97%;EN300-1179699;A856317

Chemical Property of 2-(2-Methoxyethoxy)ethanethiol

Chemical Property:

• Refractive Index: n20/D 1.4570(lit.)
• Boiling Point: 79 °C/0.7 mmHg(lit.)
• Flash Point: 78 °C
• PSA: 57.26000
• Density: 1.015 g/mL at 25 °C(lit.)
• LogP: 0.57920
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 136.05580079
• Heavy Atom Count: 8
• Complexity: 41.4

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(2-Methoxyethoxy)ethanethiol 97% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOCCS

Technology Process of 2-(2-Methoxyethoxy)ethanethiol

There total 2 articles about 2-(2-Methoxyethoxy)ethanethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester (50586-80-6,58320-73-3) → mercapto diethyene glycol monomethyl ether (88778-21-6,134874-49-0)

Guidance literature:

toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester; With thiourea; In ethanol; for 3h; Heating;

With sodium hydroxide; for 3.75h; Heating;

Reference yield:

2-(2-methoxyethoxy)ethyl alcohol (111-77-3,95507-80-5) → mercapto diethyene glycol monomethyl ether (88778-21-6,134874-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 84 percent / pyridine / 12 h / 0 °C

2.1: 33 percent aq. Na₂CS₃; CS₂ / 5 h / 65 °C

2.2: 75 percent / H₂SO₄

With pyridine; carbon disulfide; sodium trithiocarbonate;

DOI:10.1016/S0960-894X(03)00098-2

Reference yield: 100.0%

zinc(II) 5,10,15,20-tetrakis(pentafluorophenyl)porpholactone (119998-79-7) + mercapto diethyene glycol monomethyl ether (88778-21-6,134874-49-0) → meso-5,10,15,20-tetrakis(4-[2-(2-methoxyethoxy)ethane]thioxy-2,3,5,6-tetrafluorophenyl)porpholactone

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 1h; Reflux;

DOI:10.1039/c4ob00697f

upstream raw materials:

toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester

2-(2-methoxyethoxy)ethyl alcohol

Downstream raw materials:

C₁₃H₁₄N₂O₂S

4,5-[2-(2-methoxyethoxy)ethylsulfanyl]phthalonitrile

N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-(2-(2-methoxyethoxy)ethylthio)acetamide

[meso-5,10,15,20-tetrakis(4-[2-(2-methoxyethoxy)ethane]thioxytetra-2,3,5,6-fluorophenyl)porpholactonato]platinum(II)

Refernces

• 1、 Snow, Arthur W.,Foos, Edward E.. "Conversion of alcohols to thiols via tosylate intermediates". . p. 509 - 512. Retrieved 2007/10/03.