benzyl (3S,4R)-1-[(2-tert-butyldimethylsilyloxy)ethyl]-3-fluoropiperidin-4-ylcarbamate

Base Information

Chemical Name:benzyl (3S,4R)-1-[(2-tert-butyldimethylsilyloxy)ethyl]-3-fluoropiperidin-4-ylcarbamate
CAS No.:1033748-74-1
Molecular Formula:C₂₁H₃₅FN₂O₃Si
Molecular Weight:410.604
Hs Code.:

Synonyms:benzyl (3S,4R)-1-[(2-tert-butyldimethylsilyloxy)ethyl]-3-fluoropiperidin-4-ylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (3S,4R)-1-[(2-tert-butyldimethylsilyloxy)ethyl]-3-fluoropiperidin-4-ylcarbamate

Chemical Property:

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Technology Process of benzyl (3S,4R)-1-[(2-tert-butyldimethylsilyloxy)ethyl]-3-fluoropiperidin-4-ylcarbamate

There total 4 articles about benzyl (3S,4R)-1-[(2-tert-butyldimethylsilyloxy)ethyl]-3-fluoropiperidin-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1034057-93-6
benzyl ((3S,4R)-3-fluoropiperidin-4-yl)carbamate hydrochloride

: 86864-60-0
2-(tert-butyldimethylsilyloxy)ethyl bromide

: 1033748-74-1
benzyl (3S,4R)-1-[(2-tert-butyldimethylsilyloxy)ethyl]-3-fluoropiperidin-4-ylcarbamate

Guidance literature:: With caesium carbonate; In acetonitrile; at 20 - 60 ℃;
DOI:10.1021/jm300690s

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1033748-74-1
benzyl (3S,4R)-1-[(2-tert-butyldimethylsilyloxy)ethyl]-3-fluoropiperidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / 1,4-dioxane / 0.25 h / 0 °C

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 0 - 20 °C

3: caesium carbonate / acetonitrile / 20 - 60 °C

With hydrogenchloride; sodium carbonate; caesium carbonate; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm300690s

Reference yield:

: 1033748-75-2
(3S,4R)-tert-butyl 4-(((benzyloxy)carbonyl)amino)-3-fluoropiperidine-1-carboxylate

: 1033748-74-1
benzyl (3S,4R)-1-[(2-tert-butyldimethylsilyloxy)ethyl]-3-fluoropiperidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 0 - 20 °C

2: caesium carbonate / acetonitrile / 20 - 60 °C

With hydrogenchloride; caesium carbonate; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm300690s