di-tert-butyl [(3S)-4-(benzyloxy)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)butyl]phosphonate

Base Information

Chemical Name:di-tert-butyl [(3S)-4-(benzyloxy)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)butyl]phosphonate
CAS No.:1404216-92-7
Molecular Formula:C₃₃H₄₅N₄O₅P
Molecular Weight:608.718
Hs Code.:

Synonyms:di-tert-butyl [(3S)-4-(benzyloxy)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)butyl]phosphonate

Suppliers and Price of di-tert-butyl [(3S)-4-(benzyloxy)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)butyl]phosphonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of di-tert-butyl [(3S)-4-(benzyloxy)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)butyl]phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of di-tert-butyl [(3S)-4-(benzyloxy)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)butyl]phosphonate

There total 5 articles about di-tert-butyl [(3S)-4-(benzyloxy)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)butyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1166948-81-7
4-benzyloxy-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde

: 1404216-91-6
di-tert-butyl [(3S)-3-amino-4-(benzyloxy)butyl]phosphonate

: 1404216-92-7
di-tert-butyl [(3S)-4-(benzyloxy)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)butyl]phosphonate

Guidance literature:: With 2-picoline borane complex; triethylamine; In methanol; at 40 ℃;

Reference yield:

: 17123-05-6
Di-tert-butyl methylphosphonate

: 1404216-92-7
di-tert-butyl [(3S)-4-(benzyloxy)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)butyl]phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -70 °C

1.2: 0.17 h

2.1: triphenylphosphine; diphenyl phosphoryl azide; di-isopropyl azodicarboxylate / toluene / 0 - 20 °C

3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice

4.1: triethylamine; 2-picoline borane complex / methanol / 40 °C

With lithium aluminium tetrahydride; n-butyllithium; 2-picoline borane complex; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; toluene;

Reference yield:

: 13086-84-5
di-tert-butyl phosphite

: 1404216-92-7
di-tert-butyl [(3S)-4-(benzyloxy)-3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl}amino)butyl]phosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / acetonitrile; mineral oil / 0.5 h / 20 °C

1.2: 50 °C / Cooling with ice

2.1: n-butyllithium / tetrahydrofuran / 0.25 h / -70 °C

2.2: 0.17 h

3.1: triphenylphosphine; diphenyl phosphoryl azide; di-isopropyl azodicarboxylate / toluene / 0 - 20 °C

4.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice

5.1: triethylamine; 2-picoline borane complex / methanol / 40 °C

With lithium aluminium tetrahydride; n-butyllithium; 2-picoline borane complex; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; toluene; acetonitrile; mineral oil;