3,3,6,10,10,13-hexamethyl-6,13-bis(phenylmethoxy)-1,4,8,11-tetraazacyclotetradecane-5,12-dione

Base Information

• Chemical Name: 3,3,6,10,10,13-hexamethyl-6,13-bis(phenylmethoxy)-1,4,8,11-tetraazacyclotetradecane-5,12-dione
• CAS No.: 141345-63-3
• Molecular Formula: C₃₀H₄₄N₄O₄
• Molecular Weight: 524.704
• Mol file: 141345-63-3.mol

Synonyms:3,3,6,10,10,13-hexamethyl-6,13-bis(phenylmethoxy)-1,4,8,11-tetraazacyclotetradecane-5,12-dione

Chemical Property of 3,3,6,10,10,13-hexamethyl-6,13-bis(phenylmethoxy)-1,4,8,11-tetraazacyclotetradecane-5,12-dione

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3,3,6,10,10,13-hexamethyl-6,13-bis(phenylmethoxy)-1,4,8,11-tetraazacyclotetradecane-5,12-dione

There total 1 articles about 3,3,6,10,10,13-hexamethyl-6,13-bis(phenylmethoxy)-1,4,8,11-tetraazacyclotetradecane-5,12-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

(6R*,13S*)-3,3,6,10,10,13-hexamethyl-6,13-bis(phenylmethoxy)-1,4,8,11-tetraazacyclotetradeca-7(E),14(E)-diene-5,12-dione (141345-57-5) → 3,3,6,10,10,13-hexamethyl-6,13-bis(phenylmethoxy)-1,4,8,11-tetraazacyclotetradecane-5,12-dione (141345-63-3)

Guidance literature:

With camphor-10-sulfonic acid; hydrogen; palladium on activated charcoal; In dichloromethane; at 90 ℃; for 144h; under 2327.2 Torr;

DOI:10.1021/ja00039a010

Reference yield: 61.0%

2,6-bis-(bromomethyl)pyridine (7703-74-4) + 3,3,6,10,10,13-hexamethyl-6,13-bis(phenylmethoxy)-1,4,8,11-tetraazacyclotetradecane-5,12-dione (141345-63-3) → (14R,20S)-14,20-Bis-benzyloxy-11,11,14,17,17,20-hexamethyl-1,9,12,18,22-pentaaza-tricyclo[7.6.6.13,7]docosa-3,5,7(22)-triene-13,19-dione

Guidance literature:

With sodium carbonate; In acetonitrile; for 96h; Heating;

DOI:10.1021/ja994352l

upstream raw materials:

(6R^*,13S^*)-3,3,6,10,10,13-hexamethyl-6,13-bis(phenylmethoxy)-1,4,8,11-tetraazacyclotetradeca-7(E),14(E)-diene-5,12-dione