Technology Process of 6-(bromomethyl)-5-(4-chlorophenyl)pyrimidine-2,4-diamine
There total 4 articles about 6-(bromomethyl)-5-(4-chlorophenyl)pyrimidine-2,4-diamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium diisopropyl amide / Inert atmosphere
1.2: Inert atmosphere
2.1: potassium carbonate / Inert atmosphere
3.1: sodium hydrogencarbonate / dimethyl sulfoxide / 5 h / 90 °C / Inert atmosphere
4.1: hydrogen bromide; acetic acid / Inert atmosphere
With
hydrogen bromide; sodium hydrogencarbonate; potassium carbonate; acetic acid; lithium diisopropyl amide;
In
dimethyl sulfoxide;
DOI:10.1021/jm5017895
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / Inert atmosphere
2: sodium hydrogencarbonate / dimethyl sulfoxide / 5 h / 90 °C / Inert atmosphere
3: hydrogen bromide; acetic acid / Inert atmosphere
With
hydrogen bromide; sodium hydrogencarbonate; potassium carbonate; acetic acid;
In
dimethyl sulfoxide;
DOI:10.1021/jm5017895
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / dimethyl sulfoxide / 5 h / 90 °C / Inert atmosphere
2: hydrogen bromide; acetic acid / Inert atmosphere
With
hydrogen bromide; sodium hydrogencarbonate; acetic acid;
In
dimethyl sulfoxide;
DOI:10.1021/jm5017895
